Table of Contents

Original Article(continued)

1. Synthesis Characterization of Sulphadiazine Scaffold: In silico and in vitro Antibacterial Activity

   Ramakrishna Chintakunta, Harshitha Shivakumar, Sonapriyadarshini Palanikumar, Lokesh Boobal, Bharath Abbaiahreddy, Sathya Prakash Sekar

   pp. s1105-s1112 · DOI: 10.5530/ijper.20263176 · 2026

   Aim: The present study involves the synthesis, characterization, and evaluation of six novel Sulphadiazine derivatives (SV1-SS6) using Schiff base reactions with various aromatic aldehydes. Materials and Methods: The com…

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2. Computational Pharmacokinetics and Docking Insights into Conjugated Schiff Base Scaffold for Acetylcholinesterase Inhibition

   Blessy Jacob, Sarita Karole

   pp. s1113-s1119 · DOI: 10.5530/ijper.20263952 · 2026

   Aim: To evaluate the pharmacokinetic profiles and docking interactions of Schiff base scaffolds as potential Acetylcholinesterase (AChE) inhibitors using computational models. Background: Schiff bases exhibit diverse bio…

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3. In vivo and in vitro Comparative Evaluation of Delphinium denudatum and Amaranthus spinosus for Anticonvulsant Activity

   Mohd Abid, Shamim Shamim, Shadab Ali, Jiyaul Hak

   pp. s1120-s1128 · DOI: 10.5530/ijper.20262896 · 2026

   Introduction: 50 million people worldwide are affected by epilepsy, and a significant proportion suffer from side effects or respond poorly to drugs. With an established use in neurology, Delphinium denudatum (DDE) and A…

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4. Therapeutic Effects of a Polyherbal Formulation on Metabolic Dysregulation in Type 2 Diabetic Rats by LCMS

   Deepak Kumar Jha, Anushree Vabasandra Byregowda

   pp. s1129-s1138 · DOI: 10.5530/ijper.20263031 · 2026

   Aim and Objectives: This study examined the effects of a polyherbal formulation (composite of Camellia sinensis, Cinnamomum verum, Syzygium aromaticum, Curcuma longa, and Elettaria cardamomum) on lipid and glucose metabo…

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5. Lentinula edodes Polysaccharides Inhibit Estrogen Biosynthesis Enzymes in Hormone-Dependent Breast Cancer

   Chandrasekaran Ponnusamy, V V Sathibabu Uddandrao, Vadivukkarasi Sasikumar, Puniethaa Prabhu, Saravanan Ganapathy

   pp. s1139-s1155 · DOI: 10.5530/ijper.20263074 · 2026

   Background / Objective: Breast cancer, a leading cause of death among women, is closely associated with estrogen metabolism. This study investigated the potential of partially purified polysaccharides from Lentinula edod…

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6. Ethnobotanical Survey on Antidiabetic Medicinal Plants in Western Algeria: Traditional Knowledge and Public Health Implications

   Nadia Chelli, Foufa Bouabsa, Hamida Benfreha, Aicha Tir Touil, Boumediene Meddah

   pp. s1156-s1169 · DOI: 10.5530/ijper.20261753 · 2026

   Background: Type 2 diabetes is a global health challenge with significant socio-economic impacts, particularly in Algeria. Medicinal plants offer an affordable and accessible alternative to pharmaceutical treatments. Thi…

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7. Spectrometric and Chromatographic Profiling of Naringin from Citrus reticulata Blanco, Native to the Himalayan Region of Darjeeling and Sikkim

   Vishala Rani Baraily, Bhupendra Shrestha, Jithendar Reddy Mandhadi

   pp. s1170-s1179 · DOI: 10.5530/ijper.20263469 · 2026

   Aim: Citrus reticulata Blanco (CRB), widely cultivated in the Himalayan regions of Darjeeling and Sikkim, is a remarkable source of bioactive flavonoids, particularly naringin. This study presents the methodical effort t…

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8. Evaluation of Toxicity and Anti-Breast Cancer Potential of Methanolic Leaf Extract of Anastatica hierochuntica in DMBA Induced Rat Model

   Saranya Rameshbabu, Safia A. Messaoudi, Abrar B. Alsaleh, Mary Anne Wong Cordero, Kavitha Ganesh, Najwa Abdur Rashid, Raja El Hasnaoui- Saadani, Syed Ali Mohamed Yacoob

   pp. s1180-s1193 · DOI: 10.5530/ijper.20263332 · 2026

   Background: Anastatica hierochuntica has been traditionally used in herbal medicine for its therapeutic effects, but its safety and efficacy have not been comprehensively assessed. This study investigated the Methanolic …

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9. Evaluation of Berberis aristata Extract and Berberine for Anti-Oral Cancer Potential

   Vijaya Vichare, Manasi Rokade, Vaishnavi Ithape, Vrushali Tambe, Dhole Shashikant, Choudhari Vishnu

   pp. s1194-s1202 · DOI: 10.5530/ijper.20265938 · 2026

   Background: Traditional ayurveda medication Berberis aristata possesses a wide range of biological activities, including antipyretic, anti-inflammatory, anti-diabetic, and anticancer, etc. Protoberberine, berberine, and …

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10. Extraction, Phytochemical Analysis, and Antioxidant Activity of Adhatoda vasica Leaves

    Hameed Fathima Kamal, Jaideep Mahendra, Ashok Kumar Pandurangan

    pp. s1203-s1214 · DOI: 10.5530/ijper.20264592 · 2026

    Background: Adhatoda vasica is a well-known medicinal plant with diverse therapeutic properties, widely used in traditional medicine. Its phytochemical composition and antioxidant potential warrant detailed investigation…

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11. Insulin-Sensitizing Effect of Buchanania lanzan Leaf Extract: Integrated Computational and in vivo Evidence

    Rubina Usman Watangi, Nayeem Ashrafali Khatib, Sunil Tuakaram Galatage, Arehalli Sidramappa Manjappa, Tufailahmad Basheerahmad Sajjan, Ekta Uday Kotharkar, Rajkumar Sanjay Patil

    pp. s1215-s1230 · DOI: 10.5530/ijper.20264345 · 2026

    Background: Buchanania lanzan Spreng. is a plant having anti-diabetic, anti-inflammatory properties. Aim: The aim of this research is to assess methanolic extract of Buchanania lanzan leaves for insulin sensitivity in di…

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12. Antidiabetic and Hepatoprotective Effects of Dichrostachys cinerea Bark Extract in Streptozotocin-Induced Diabetic Rats

    Suha Mujahed Abudoleh, Qais Abualassal, Zead Helmi Abudayeh, Zain Alabden Ghanim Ahmed Ahmed, Samer Hasan Hussein-Al-Ali, Kowsalya Ramalingam, Shilpa Perumal Narasimhamoorthi, Palanisamy Arulselvan, Karunakaran Saravanan, Subbarayan Sarathbabu

    pp. s1231-s1239 · DOI: 10.5530/ijper.20263929 · 2026

    Background: Diabetes mellitus is a complex metabolic disorder characterized by chronic hyperglycemia resulting from impaired insulin secretion, insulin action, or both. Persistent hyperglycemia is often accompanied by se…

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13. Drug-Excipients Compatibility Studies of Molnupiravir in an Attempt of Developing a Stable Molnupiravir Capsule Formulation for the Treatment of COVID-19

    Sumit Agarwal, Rajasekaran Sidhan

    pp. s1240-s1245 · DOI: 10.5530/ijper.20262891 · 2026

    Background: Molnupiravir is an antiviral medication primarily used for the treatment of COVID-19. Clinical trials have shown that molnupiravir reduces the risk of hospitalization and death due to COVID- 19 when taken ear…

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14. Fabrication of a Cost-Effective in-House Electrode Assembly for Recording EEG and Behavioral Seizures in Unrestrained Rats

    Nitin Yadav, Radhika Mittal, Arzoo Chaudhary, Priya Priya, Jyotirmoy Banerjee, Aparna Banerjee Dixit

    pp. s1246-s1252 · DOI: 10.5530/ijper.20263671 · 2026

    Background: Electroencephalography (EEG) is a valuable tool in neuroscience research for analyzing epileptic seizures in animal models. However, the cost that comes with commercial electrode assemblies is a critical chal…

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15. Optimized Green Synthesis Approaches of Phenytoin Using Divalent Sulfate Salts and Chromatographic Purity Assessment via A Novel RP-HPLC Method

    Arka Chakraborty, Rajarshi Nath, Biplab Debnath, Arijit Das, Anindya Bose, Shambo Panda

    pp. s1253-s1260 · DOI: 10.5530/ijper.20262650 · 2026

    Background: Phenytoin is a first-line anti-epileptic drug. Conventionally, It is synthesized by using Benzil and urea in the presence of concentrated HCl. Our aim is to increase the yield as well as the purity of Phenyto…

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16. Establishment of a Sensitive and Stability-Indicating RP-HPLC Protocol for Co-Quantification of Empagliflozin and Sitagliptin

    Rahil Desai, Mitali Dalwadi, Umesh Upadhyay

    pp. s1261-s1266 · DOI: 10.5530/ijper.20262811 · 2026

    Aim/Background: To develop a stability-indicating RP-HPLC method for simultaneous quantification of Empagliflozin (EMPA) and Sitagliptin (SITA) in a synthetic mixture for quality control and stability studies. Materials …

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17. QbD-Driven Hydrotropic UV Method for Simultaneous Quantitation of Poorly Soluble Drugs, Irbesartan and Hydrochlorothiazide in Bulk and Tablet Formulation

    Aggarapu Susmitha, Galla Rajitha

    pp. s1267-s1278 · DOI: 10.5530/ijper.20261652 · 2026

    Background: Developing a reliable and precise method for the simultaneous quantitation of poorly soluble drugs, Irbesartan (IRB) and Hydrochlorothiazide (HCTZ), in bulk and formulations poses significant challenges due t…

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18. Validation of Effective β-Lactum Antibiotics in Available Dosage Forms by RP-HPLC Developed Analytical Chromatographic Method

    Suchitra Duddagi, Shravan Kumar Konda, Jagadish Tota, Shushma Akula, Pavan Kumar Kasu

    pp. s1279-s1284 · DOI: 10.5530/ijper.20261898 · 2026

    Background: Vaborbactam and Meropenem are co-formulated in pharmaceutical tablets for enhanced antibacterial activity. A simple, economical, and reliable analytical method is required for their simultaneous quantificatio…

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19. QbD Assisted Method Development and Validation of Stability Indicating UV Spectrophotometric Method for Azelnidipine

    Kirankumar Jalindar Gavali, Meenaxi Maruti Maste, Nikhil Sunil Gawas, Shailendra Sanjay Suryawanshi

    pp. s1285-s1298 · DOI: 10.5530/ijper.20261963 · 2026

    Background: Azelnidipine, calcium channel blocker used in hypertension management, requires reliable analytical method to ensure its stability, quality, and regulatory compliance. Stability-indicating methods are essenti…

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20. Analytical Verification and Studies on Degradation of Voglibose Nanocrystals Formulations using the Quantitative RP-HPLC Method

    Preeti Aneja, Rajender Guleria, Dev Praksh Dahiya, Mohanraj Swaminathan

    pp. s1299-s1309 · DOI: 10.5530/ijper.20262024 · 2026

    Introduction: The primary goal of the experiment was to validate a method for identifying Voglibose content in a newly developed Nano formulation specifically Nanocrystals. For estimating the content of voglibose in drug…

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