Table of Contents

Original Article(continued)

1. Effect of Curcumin and Dioscorea alata L. On Aniline Induced Spleen Toxicity in Rats

   Pratiksha Shewale, Ziyaurrahman Ataurrahman, Yash Bachhav, Kavita Bhavar, Yogesh Ahire, Vinod Bairagi

   pp. 1143-1151 · DOI: 10.5530/ijper.20261638 · 2026

   Background: In this investigation, the consequences of standardized ethanolic extracts of curcumin and Dioscorea alata L. To assess their therapeutic potential individually and together in spleen poisoning caused by anil…

   TextPDFLens

2. Xing Xia Di Tan Decoction Enhances Microwave Ablation and Chemotherapy in Lung Cancer: Molecular Insights from Network Pharmacology

   Peixi Chen, Junming Huang, Shaoshan Du, Sili Deng

   pp. 1152-1158 · DOI: 10.5530/ijper.20263058 · 2026

   Background/Aim: Non-small cell lung cancer (NSCLC) accounts for most lung cancer cases and remains a major health burden. Many elderly patients cannot tolerate targeted or immune therapies, or develop resistance, undersc…

   TextPDFLens

3. Synthesis, Structural Properties and Antibacterial Activity of Vorinostat Loaded on Carbon Nanotubes or Iron Oxide Nanoparticles

   Dhulfiqar Abed, Saba Abdulmunem Habeeb, Lena Fadhil Al-Jibouri, Asmaa Hashim Hammadi, Noor Zuhair Kbah

   pp. 1159-1168 · DOI: 10.5530/ijper.20261673 · 2026

   Background: In this work, Carbon Nanotubes (CNTs) and Iron Oxide Nanoparticles (IONPs) were successfully synthesized and their antibacterial activity were evaluated against Staphylococcus aureus (Gram-positive) and Pseud…

   TextPDFLens

4. Monoamine Oxidase Inhibition Activity of Ziziphus jujube Mill. Fruit Extracts in Chronic Unpredictable Stress Rats

   Mrinal Sharma, Payal Mittal, Pradeep Goyal

   pp. 1169-1179 · DOI: 10.5530/ijper.20262858 · 2026

   Background: In the current healing synopsis, no allopathic drug is available that can renew the pathogenic development of neurodegenerative conditions, to a degree of concavity, a shift towards everyday remedies is neede…

   TextPDFLens

5. Neuroprotective Effects of Conessine in Beta-Amyloid-Induced SH-SY5Y Cells in vitro

   Dandan Zhang, Jun Wu, Amirah Albaqami, Wedad Mawkili, Faten F. Bin Dayel, Tahera Waheed Alnassfan

   pp. 1180-1188 · DOI: 10.5530/ijper.20263491 · 2026

   Objectives: Alzheimer’s Disease (AD) is a brain disorder that affects the memory and thinking ability of the patient, characterised by beta-amyloid (Aβ) plaque accumulation, oxidative stress, impaired autophagy, and neur…

   TextPDFLens

6. Phytochemical Profiling and Evaluation of Cytotoxic Potential of Cucumis prophetarum L. Fruit Extract

   Sadique Akhtar Javed, Asaad Khalid, Rym Hassani, Syam Mohan, Ashraf Nabiel Abdalla, Zia ur Rehman, Asim Najmi, Khalid Zoghebi, Hafiz Antar Makeen, Mohammed Albratty

   pp. 1189-1198 · DOI: 10.5530/ijper.20262051 · 2026

   Objectives: The present study examined phytochemical composition of ethanolic extract and evaluated cytotoxic properties of Cucumis prophetarum L. Materials and Methods: Phytochemical composition of extract was evaluated…

   TextPDFLens

7. Investigation of Potential of Oxalis corniculata Through Inhibition of Matrix Metalloproteinases for the Treatment of Skin Photoageing: An in silico Approach

   Madhuri Baghel, Sushil Bhargav

   pp. 1199-1205 · DOI: 10.5530/ijper.20266452 · 2026

   Background: O. carniculata contains bioactive substances called C-glycosyl-flavones that have antioxidant and anti-inflammatory properties. The inhibitory effect of C-glycosyl-flavones of O. carniculata on MMPs was estab…

   TextPDFLens

8. Decoding the Anticancer Mechanism of Action of Kaempferol in Liver Cancer Cells via Transcriptomics, Network Pharmacology, Molecular Docking, Dynamics Simulations, and in vitro Validation

   Zhen He, Wei Liu, Na Su, Guoqiang Xing

   pp. 1206-1217 · DOI: 10.5530/ijper.20262120 · 2026

   Background: Kaempferol, a dietary flavonoid with proven antioxidant and antiinflammatory properties, has garnered significant interest in cancer research for its ability to modulate multiple oncogenic pathways, making it…

   TextPDFLens

9. Inhibition of miR-224 Repressed Cell Growth, Migration and Invasiveness in Gastric Cancer

   Changming Shao, Qinshu Shao, Yingyu Ma

   pp. 1218-1223 · DOI: 10.5530/ijper.20263262 · 2026

   Aim/Background: MiR-224 has been reported to be associated with many cancers, however, the role of miR-224 in gastric cancer was unclear. Materials and Methods: In the present study, we first used RT-PCR to detect miR-22…

   TextPDFLens

10. A Glimpse of the Interaction between N-Nitrosamines and HPV E5 in Rodent Cell Transformation

    Hongwei Liu, Shuying Li, Jintao Li

    pp. 1224-1232 · DOI: 10.5530/ijper.20263287 · 2026

    Background: A few epidemiologic surveys and experimental studies observed the synergistic carcinogenic effect of nitrosamines and High-Risk Human Papillomavirus (HPV) in partial digestive tract cancers. They mainly focus…

    TextPDFLens

11. Pro-inflammatory Cytokine TNF-α Reduces Matrix Calcification in Papillary Thyroid Carcinoma

    Junyi Fu, Yu Xi, Jianhua Niu

    pp. 1233-1240 · DOI: 10.5530/ijper.20263458 · 2026

    Aim/Background: Tumor Necrosis Factor-α (TNF-α) is a key pro-inflammatory cytokine involved in immune regulation, chronic inflammation, and tumor progression. However, its role in the calcification process of thyroid mal…

    TextPDFLens

12. Targeting PARP1 by Small Molecule Drugs for the Therapeutics of Gynaecological Cancers

    Adel I. Alalawy

    pp. 1241-1248 · DOI: 10.5530/ijper.20261925 · 2026

    Background: In gynaecological cancers like ovarian, endometrial, and cervical cancer, where DNA damage repair mechanisms are frequently dysregulated, targeting PARP1 offers a targeted therapeutic approach. Materials and …

    TextPDFLens

13. Simvastatin Promotes Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells by Regulating the BMP-2/ Smads Signaling Pathway

    Chen Tang, Fang Qian, Lijuan Wang, Shiya Li

    pp. 1249-1255 · DOI: 10.5530/ijper.20263499 · 2026

    Objectives: This study aimed to investigate whether simvastatin could promote the osteogenic differentiation of Bone Marrow Mesenchymal Stem Cells (BMSCs) by modulating the BMP-2/ Smads signaling pathway and to elucidate…

    TextPDFLens

14. TSH Suppression Induces Anxiety- and Depression-like Behaviors in Rats, With Hippocampal 5-HT Loss, Notch Activation, and a Neurogenesis-Apoptosis Imbalance

    Yikun Zhao, Honglin Jiang, Huiyuan Shang, Zhongyuan Xia

    pp. 1256-1267 · DOI: 10.5530/ijper.20264130 · 2026

    Background: TSH suppression is widely used in thyroid cancer management; however, its neurobehavioral consequences are not well understood. Objectives: To evaluate the impact of TSH suppression on emotion-related behavio…

    TextPDFLens

15. Exploring the Mechanism of Isoliquiritigenin on Lung Cancer Based on Network Pharmacology and Molecular Docking

    Guibin Weng, Weimin Fang, Weikun Su, Lin Chen, Menglin Liao, Yijin Lin

    pp. 1268-1275 · DOI: 10.5530/ijper.20260503 · 2026

    Objectives: This study aims to explore how Isoliquiritigenin (ISL) combats lung cancer by using network pharmacology and molecular docking techniques. Materials and Methods: We used multiple databases to find ISL-related…

    TextPDFLens

16. Crafting Cancer-Fighting Wonders: Synthesis, Characterization, and Evaluation of a Novel Thiazole Derivative Targeting EGFR

    Prabodh Vinayak Sapkale, Avinash Vishwanath Patil

    pp. 1276-1283 · DOI: 10.5530/ijper.20267061 · 2026

    Aim: The development of novel thiazole derivatives, namely PVS 3.1, 3.2, 3.3, and 3.4, marks a significant advancement in the field of anticancer drug discovery. These compounds were synthesized using an efficient, time-…

    TextPDFLens

17. 1-(4-Aminophenyl)-3-Morpholinopiperidin-2-One: A Process Related Impurity of Apixaban- An Anticoagulant Drug

    Vipin Kumar, Sachin Kumar Sharma, Govind Singh, Shyambaran Dhuriya, Lingaiah Balthu, Sushilkumar, Rashmi Devi, Krishna Kumar Yadav, Priyanka Mathur, Sumit S. Chourasiya

    pp. 1284-1292 · DOI: 10.5530/ijper.20261932 · 2026

    Introduction: Apixaban is an anticoagulant drug act by direct inhibition of factor Xa. Apixaban is used for the treatment and prevention of blood clots and stroke in people with nonvalvular atrial fibrillation. In this r…

    TextPDFLens

18. Analytical Quality by Design Enabled HPTLC Method for Estimation of Phytoconstituents Andrographolide, Piperine and Quercetin in Nilavembu Kudineer

    Sivagami Bojan, Sailaja Bandhakavi, Chandrasekar Raju, Niranjan Babu Mudduluru

    pp. 1293-1303 · DOI: 10.5530/ijper.20261651 · 2026

    Background: This work outlines a sensitive, cost-effective, reliable and ecofriendly novel AQbD approach based HPTLC for the simultaneous determination of standard samples of Andrographolide (A), Piperine (P) and Quercet…

    TextPDFLens

19. Bioanalytical Method Development and Validation of an LC-MS/MS Method for the Quantitation of Fruquintinib in Rabbit Plasma

    Thota Manasa, Kumaraswamy Gandla

    pp. 1304-1310 · DOI: 10.5530/ijper.20262575 · 2026

    Aim: An LC-MS/MS method is needed to accurately measure the concentration of Fruquintinib in a biological sample. This method should be both specific and sensitive. Materials and Methods: The processed materials were sep…

    TextPDFLens

20. Integration of Green Analytical Chemistry and Quality by Design Approach for Systematic Development of Stability-Indicating RP-HPLC Method for Estimation of Guanfacine

    Kiran Narayan Gaikwad, Mahesh Palled

    pp. 1311-1325 · DOI: 10.5530/ijper.20262597 · 2026

    Background: Guanfacine, a phenylacetyl-guanidine derivative, has gained pharmaceutical significance due to its therapeutic applications. A stability-indicating, Quality by Design (QbD)- based RP-HPLC method was developed…

    TextPDFLens