Monoamine Oxidase Inhibition Activity of Ziziphus jujube Mill. Fruit Extracts in Chronic Unpredictable Stress Rats

Abstract

Background: In the current healing synopsis, no allopathic drug is available that can renew the pathogenic development of neurodegenerative conditions, to a degree of concavity, a shift towards everyday remedies is needed. Ziziphus jujube Mill., Rhamnaceae, is a medicinal plant with flavonoids and tannins that augments depressing conditions. Aim: The current work evaluated the therapeutic potential of the ethanolic and water extract of Ziziphus jujube for MAO inhibition in the chronic unpredictable stress model of depression. Materials and Methods: The current study examined the anti-depressant potential of ethanolic and water extracts (200 mg/kg) of Ziziphus jujube crop by highlighting the plant’s very favourable pharmacological traits, through observing allure affect changes of despair-like attitude in a never-ending changeable stress rat model of concavity by sucrose preference test, tail suspension test and biochemical parameters. Results: The chronic changeable stress-inferred depressing rats doctored accompanying the ethanolic and water extract showed the usual antagonistic-depressing-like action, containing the important increase in sucrose use in hydrogen predilection test, an important decline in the immobility occasion two together in compulsory swimming test and tail delay test, and an increase in bridge and rising in the open second phase testing. Besides, decreased Monoamine Oxidase levels (MAO-A and MAO-B), deteriorated lipid peroxidation MDA levels, and improved superoxide dismutase and glutathione-S-transferase exercise. Conclusion: The study results provide the first evidence that an ethanolic and water extract of Ziziphus jujube has an antidepressant effect due to its monoamine-burning restriction effect and can increase the likelihood of cultivating new restlessness-depressant plant species.