Table of Contents

Original Article(continued)

1. Therapeutic Evaluation of Camel Milk-Derived Lactoferrin for in vivo Anti-Arthritic Efficacy

   Anchit Dogra, Avijit Mazumder, Saumya Das, Pratibha Pandey, Motamarri Venkata Naga Lalitha Chaitanya

   pp. s626-s632 · DOI: 10.5530/ijper.20254695 · 2025

   Background: Arthritis is a prevalent chronic inflammatory condition that significantly impacts individual’s quality of life. Lactoferrin (Lf), a multifunctional glycoprotein found in CM, has shown promising anti-inflamma…

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2. Role of Brain Ang (1-7) With Combination Therapy of Aliskerin in Control of Diabetic Nephropathy

   Richa Shakya, Jeetendra Kumar Gupta, Avijit Mazumder

   pp. s633-s640 · DOI: 10.5530/ijper.20255883 · 2025

   Objectives: Angiotensin (1-7) system has been recognizing as physiologically major content of the renin-angiotensin system. It exhibited that Diabetic Nephropathy (DN), which is prevalent causes of end-stage renal diseas…

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3. Optimizing 3D Structural Predictions of Murine β2-Adrenergic Receptor: Swiss-Model Outperforms AlphaFolds

   Vijayalakshmi Gangadhara, Asha Abraham

   pp. s641-s655 · DOI: 10.5530/ijper.20256524 · 2025

   Background and Aim: The β2 adrenergic receptor is vital in physiological processes and a key target for metabolic syndrome. Understanding the structural attributes of the murine β2-AR is crucial for comprehending metabol…

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4. Microwave-Assisted Synthesis and Characterization of N-Vinyl-2-Pyrrolidone Grafted Almond Gum: A Natural Dietary Polysaccharide for Controlled Release of Diclofenac Sodium

   Snehal Pawar, Sopan Nangare, Premkumar Baviskar, Laxmikant Zawar

   pp. s656-s669 · DOI: 10.5530/ijper.20256712 · 2025

   Background: Gums occurring in nature are widely used in pharmaceuticals for their unique properties and diversified applications. The natural gums are almost safely consumed as food additives as well as drug carriers, al…

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5. Bioanalysis and Validation of Fesoterodine, an Antimuscarinic Agent and its Active Metabolite Using Liquid Chromatography with Tandem Mass Spectrometry

   Vijaya Lakshmi Marella, Suneetha Achanti, Kanaka Durga Devi Nelluri, Himaja Nara, Anusha Thondepu, Ramatilaka Unnam, Chetan Mokkapati, Penta Dolly Chaitanya Sudha

   pp. s670-s679 · DOI: 10.5530/ijper.20250467 · 2025

   Aim: To establish a bioanalytical method with rapid, specific and sensitiveness with tandem mass spectrometric with liquid chromatography for an anti-muscuranic agent, fesoterodine and its metabolite, 5-hydroxy methyl to…

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6. Method Development for Estimation of Azelnidipine and S (-) Metoprolol Succinate in Tablets by UV Spectrophotometry and HPLC Using Student’s T-Test

   Saylee Ganorkar, Aditya Bhavsar, Rahul Khiste

   pp. s680-s688 · DOI: 10.5530/ijper.20253109 · 2025

   Introduction: Azelnidipine a calcium channel blocker belongs to BCS class II and S (-) Metoprolol Succinate belongs to BCS class I. Rationale: Calcium is responsible for inducing smooth muscle contraction. Inhibiting cal…

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7. Quality by Design (QbD) Based Development and Validation of RP-HPLC Method for Simultaneous Estimation of Metformin and Teneligliptin in Bulk and their Pharmaceutical Formulation

   Jagatkumar Upadhyay, Shantilal Padhiyar, Kamlesh Jivani, Tejas Patel, Vashisth Bhavsar, Vipul Prajapati

   pp. s689-s704 · DOI: 10.5530/ijper.20253717 · 2025

   Aim: To develop and validate simple, accurate, precise, sensitive and robust Reversed Phase High Performance Liquid Chromatographic (RP-HPLC) method for simultaneous estimation of metformin and teneligliptin in bulk and …

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8. Response Surface Methodology as a Tool for Stability-Indicating Method Development and Validation for the Determination of Selective EZH2 Inhibitor

   Srujani Chimpiri, Deva Rani, Mastanamma Shaik, Madhuri Desavathu, Ankit Gupta

   pp. s705-s715 · DOI: 10.5530/ijper.20254323 · 2025

   Background: Tazemetostat (TZST) is an efficient first-in-class, selective, EZH2 oral inhibitor which had demonstrated tumor regression and favourable safety in patients with Epithelioid Sarcoma. Methods developed using A…

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9. Spectrophotometric Simultaneous Equation and Area under the Curve Methods for Estimation of Metoprolol Succinate and Telmisartan in Pure Drugs and its Combined Marketed Formulation

   Vivek Sharma, Rina Das, Dinesh Kumar Mehta, Anu Chaudhary, Samir Patel, Archita Jayendrakumar Patel

   pp. s716-s723 · DOI: 10.5530/ijper.20255416 · 2025

   Background: Telmisartan-metoprolol succinate formulations treat hypertension. The primary goal was to develop and evaluate a UV-spectrophotometric method for estimating telmisartan and metoprolol succinate in a combinati…

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10. QbD-Enhanced HPLC Method Development for Vildagliptin and Metformin HCl Formulations

    Pankaj Sopan Hasabe, Kishor Vinayak Gaikwad, Venketa Satyanarayana Nandmuri, Akanksha Govind Kolekar, Kalyanraman Lakshmi Narayanan, Samadhan Prakash Pawar

    pp. s724-s732 · DOI: 10.5530/ijper.20256263 · 2025

    Objectives: This research employs the Quality by Design strategy to design an optimized High-Performance Liquid Chromatography method aimed at analyzing vildagliptin and metformin hydrochloride in pharmaceutical dosage f…

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11. Development and Validation of UV/visible Spectrophotometric Method for Estimation of Piroxicam from Bulk and Formulation

    Sandip Mohan Honmane, Kunal Rajaram Yadav, Yuvraj Dilip Dange, Suraj Nijamso Pattekari, Shradha Shivdayal Tiwari, Mahesh Govind Saralaya

    pp. s733-s739 · DOI: 10.5530/ijper.20256898 · 2025

    Background: Piroxicam (PRX) is a potent anti-inflammatory medicine used both orally and topically to treat arthritis, gout, and other inflammatory disorders. Developing and testing an effective analytical technique is cr…

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12. Development and Validation of a HPLC-PDA Method to Quantification of Ketobemidone in Rat Plasma and its’ Application in Pharmacokinetic Study

    Shashipal Aitha, Subramani Devaraju, Jayanti Naga Sri Rama Chandra Murthy, Kiran Kumar Tatapudi, Leela Prasad Geddada, Tiruveedhula Somasekhar, Hemambika Sadasivuni, Muralidharan Kaliyaperumal

    pp. s740-s747 · DOI: 10.5530/ijper.20256924 · 2025

    Aim: Ketobemidone is an opioid drug that have been using against pain in various circumstances. The current research was aimed to develop and validate a HPLC-PDA method to estimate the ketobemidone in rat plasma. Materia…

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13. Spiked Human Plasma Samples: Stability Indicating Method Development and Validation of Pexidartinib by LCMS

    Velagapudi Naga Venkata Kishore, Giri Prasad Gorumutchu, Khandapu Bala Murali Krishna

    pp. s748-s757 · DOI: 10.5530/ijper.20256947 · 2025

    Aim: Pexidartinib (PDTB) was utilized in the development of a novel bioanalytical LCMS method in human plasma, with Talazoparib (TZPB) serving as the IS (Internal standard). Materials and Methods: The chromatographic sep…

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14. Advanced Solid Phase Extraction Tools for Measuring Bempedoic Acid and its Active Metabolite in Human Plasma by Using LC-MS/MS

    Mahesh Meghavath, Nayakanti Devanna

    pp. s758-s768 · DOI: 10.5530/ijper.20257284 · 2025

    Aim/Background: To simultaneously measure bempedoic acid and its primary metabolite, bempedoic acid metabolite-ESP15228, in human plasma via UPLC-MS/MS, the QuEChERS extraction tactic is not suitable. Instead, employ a t…

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15. Bilosome Nanocarriers for Enhanced Oral Bioavailability and Cardiovascular Activity of Milrinone

    Kiruthika Santhinathan, Susmitha Durai, Rijivana Sirajudeen, Gopinath Govindhraji, Saravanan Gopal, Gayathri Kumararaja

    pp. s769-s775 · DOI: 10.5530/ijper.20250292 · 2025

    Background: Cardiovascular Diseases (CVDs) are the main causes of death in both industrialized and developing nations, which are mostly brought on by poor lifestyles and insufficient physical activity. Recent years many …

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