Table of Contents

Research Article(continued)

1. Design, Optimization, and in vitro Evaluation of Orally Disintegrating Tablets Containing Amlodipine Besylate

   Sevinç Şahbaz, Setenay Özer-Önder, Timuçin Uğurlu

   pp. 1205-1214 · DOI: 10.5530/ijper.58.4.133 · 2024

   Background: In this study, it was aimed to prepare orally disintegrating tablet formulations of amlodipine besylate by applying the experimental design. Materials and Methods: A face-centered, central composite 32 full f…

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2. Formulation of Pregabalin-Loaded Trimethyl Chitosan Microspheres for Nasal Drug Delivery: In vitro, ex vivo and in vivo Characterization

   Sonwane Priyanka, Qutub Mohammad, Umekar Milind, Taksande Jayshree

   pp. 1215-1224 · DOI: 10.5530/ijper.58.4.134 · 2024

   Background: Polar drugs make it difficult to cross nasal cells. Trimethyl Chitosan (TMC) microspheres help absorption by opening junctions, increasing drug retention. Pregabalin absorbs well orally but delays crossing th…

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3. Synthesis, Anti-inflammatory and in silico Studies of few novel 1,2,4-Triazole Derived Schiff Base Compounds

   Deepanshu Vishwakarma, Surya Prakash Gupta

   pp. 1235-1241 · DOI: 10.5530/ijper.58.4.136 · 2024

   Background: Every year more than 1 billion prescriptions are written for all NSAIDs and yet the quest to develop new NSAIDs remains prominent. Objectives: The current investigation's goal was to synthesize and assess the…

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4. Coumarin-1,2,3-Triazole Hybrids as Promising Antibacterial Agents: In silico Molecular Docking, ADMET and Molecular Dynamics Simulation Studies (Exploring in silico Antibacterial Potential of Coumarin-1,2,3-triazoles)

   Krishna Narayan Mishra, Mayank Rashmi, Harish Chandra Upadhyay

   pp. 1242-1254 · DOI: 10.5530/ijper.58.4.137 · 2024

   Background: A lot of coumarin-1,2,3-triazole hybrids have been reported to show antibacterial activities, but most of them are unexplored in clinical studies. Herein, we wish to apply in silico docking, physiochemical pr…

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5. A Simultaneous Quantification of Four Potential Genotoxic Impurities Purinediol Hydrochloride, N7-Isomer, Monoalkyl Contaminant and Diacetyl Purine Present in Penciclovir Using LC-MS/MS

   Nagasurendra Reddy Varampati, Devanna Nayakanti

   pp. 1255-1266 · DOI: 10.5530/ijper.58.4.138 · 2024

   Background: Penciclovir is a medication for antiviral therapy for curing different kinds of herpes virus infections. The four contaminants are the starting materials of Penciclovir which are present at a trace level in t…

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6. Electrometric Study on Nature and Stability of CoII, NiII and CuII Complexes with 5-Sulfosalicylic Acid in DMSO-Water Mixtures

   Malla Balakrishna

   pp. 1267-1276 · DOI: 10.5530/ijper.58.4.139 · 2024

   Background: The bioavailability of an element and its toxicity based on its chemical species. According to IUPAC the concept of chemical speciation is defined as it is a form of an element according to its oxidation stat…

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7. HR-LCMS Metabolite Profiling and in silico Evaluation of the Antidiabetic Activity of Methanolic Leaf Extract of Chrozophora rottleri (Geiseler) A. Juss. Ex Spreng.

   Srilakshmi Nallapaty, Narender Malothu, Sathish Kumar Konidala, Anka Rao Areti, Chakravarthi Guntupalli

   pp. 1277-1286 · DOI: 10.5530/ijper.58.4.140 · 2024

   Background: Chrozophora rottleri (Geiseler) A. Juss. ex Spreng. is a well-known traditional medicinal plant with a complex biological profile, though inadequate research has been established on its possible anti-diabetic…

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8. GCMS and LCMS/MS Based Analysis for the Identification and Characterization of Bioactive Metabolites of Seaweed Kappaphycus striatus as an Anti-hypertensive and Anti-hypercholesterolemic Agent

   Hannis Fadzillah Mohsin, Zolkapli Eshak, Sadia Sultan, Wasim Ahmad, Mohammad Humayoon Amini, Kamran Ashraf

   pp. 1287-1298 · DOI: 10.5530/ijper.58.4.141 · 2024

   Background: Over 50% of the population in Malaysia has hypercholesterolemia, which puts them at a high risk of cardiovascular disease. Both food sources and the ingredients in traditional medications are essential to the…

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9. Development and Validation of a New RP-HPLC Method for the Simultaneous Estimation of Nirmatrelvir, Ritonavir and Molnupiravir in Formulated Nanosponges, Plasma Samples and its Pharmacokinetic Study

   Vyshali Veerareddy, Kumaraswamy Gandla

   pp. 1299-1310 · DOI: 10.5530/ijper.58.4.142 · 2024

   Background: Nirmatrelvir and Ritonavir are used in combination (Paxlovid®) in order to treat COVID-19. Thus, the goal of the current study was to create an easy-to-use, accurate, and sensitive method for the preparation …

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10. A Cross-Sectional Study of Community Attitude towards Herbal Products against Hepatobiliary Diseases in Northern Cyprus

    Umut Sõzüõz, Azmi Hanoğlu, Fehmi Burak Alkaş, Duygu Yiğit Hanoğlu, Ali Hikmet Meriçli, Dudu Őzkum Yavuz

    pp. 1311-1317 · DOI: 10.5530/ijper.58.4.112 · 2024

    Aim: The study in Northern Cyprus aimed to improve patient-centered care and healthcare practices by examining community perceptions of Herbal Products (HPs) for liver and biliary diseases. Materials and Methods: The sel…

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11. Evaluation of the Knowledge, Opinion, and Approaches of Pharmacists, Physicians, Dieticians, and the Public on Herbal Products Used for Weight Control and Slimming in Northern Cyprus

    Bariş Şendal lzzet, Hasan Ulaş Yavuz, Dudu Özkum Yavuz

    pp. 1318-1327 · DOI: 10.5530/ijper.58.4.111 · 2024

    Background: This study explores the perspectives of Northern Cyprus (NC) pharmacists, physicians, dieticians, and the public regarding Herbal Products (HP) for Weight Control (WC) and slimming, contributing valuable insi…

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12. A Prospective Observational Study on Assessment of Risk Factors, Complications and Clinical Efficacy of Hepatoprotectives and Antimicrobials in Treatment of Liver Diseases at Tertiary Care Teaching Hospital in Telangana

    Jaya Sollu, Mounika Pulusu, Deepthi Peddaramamolla, Jharna Islam, Nikhil Soma, Chinnaeswaraiah Maram

    pp. 1328-1335 · DOI: 10.5530/ijper.58.4.143 · 2024

    Background: The liver serves a variety of essential purposes, making it the most important organ. Chronic liver disease (CLD) has a wide range of etiologies, including toxins, alcoholism, infections, autoimmune illnesses…

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13. Augmented Optical Retention and Improved Antibacterial Activity against Conjunctivitis of Moxifloxacin Hydrochloride Entrapped in Microsponges in situ Gel: Formulation Evaluation and in vivo Remedial Value in Rabbits

    Sangeet Kumar Sharma, Ishab Kumar, Ankur Rohilla, Ramchander Khatri, Tanuj Hooda, Seema Rohilla

    pp. 1336-1347 · DOI: 10.5530/ijper.58.4.144 · 2024

    Objectives: Moxifloxacin hydrochloride is an antibiotic related to flouroquinolones class. It possessed reasonable to exceptional efficacy against gram-negative ocular pathogens. The prime goal of this study was to formu…

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14. Silencing PDCD4 Mediates TFEB Overexpression Promoting Proliferation, Migration and Invasion of Cervical Cancer HeLa Cells

    Xing Gao, Ziying Liang, Yanan Yuan, Wenbo Liu

    pp. 1348-1355 · DOI: 10.5530/ijper.58.4.145 · 2024

    Aim/Background: Cervical cancer is a common gynecologic malignant tumor, its occurrence and development are related to genetic and environmental factors. Recent studies have shown that Programmed Cell Death 4 (PDCD4) and…

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15. Strategic Targeting of Plasmodium Dihydroorotate Dehydrogenase through Antimicrobial Artemisinin Chiral Centers and their Derivatives: An Integrative Study Using Network Pharmacology and Isothermal Titration Calorimetry

    Zia ur Rehman

    pp. 1356-1372 · DOI: 10.5530/ijper.58.4.146 · 2024

    Background: Developing effective antimalarial medications requires understanding the interactions between Plasmodium Dihydroorotate dehydrogenase (DHOdehase) and Artemisinin, including its fourteen stereoisomers (R/S) wh…

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16. The Effect of Sophoridine on NSCLC by Down Regulation of mTOR and NOTCH1

    Mohammad Raghibul Hasan, Ali Hazazi, Ahad Amer Alsaiari, Fawaz M. Almufarriji, Amirah Albaqami, Osama Abdulaziz, Marwa K Darwish, Atul Kumar, Kapil Dev, Mohammed Ageeli Hakami

    pp. 1373-1379 · DOI: 10.5530/ijper.58.4.147 · 2024

    Introduction: Sophoridine, an alkaloid compound which is isolated from various plant species like Sophora alopecuroides and Sophora flavescens. It identified to have potential pharmacological properties, including anti-i…

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