Volume 59, Issue 2

Original Article(continued)

1. Investigating the Anti-Inflammatory, Antioxidant and Apoptotic Protein Inhibition Study of Berberine on Diabetic Retinopathy in Rats

   Lihui Wang, Wei Fei, Chongjuan Qin, Jing Zhang

   pp. 647-654 · DOI: 10.5530/ijper.20250344 · 2025

   Background: Globally, Diabetic Retinopathy (DR) is a leading cause of vision loss. This disease, which impacts the microvasculature of the retina, is brought on by the oxidative stress linked to diabetes. Several studies…

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2. Identification of Novel Drug Targets and Potential Antibacterial Traditional Chinese Medicine Compounds for Klebsiella pneumoniae through in silico and Antibacterial Activity Evaluation

   Yanping Li, Suresh Kumar, Hao Peng, Lihu Zhang

   pp. 655-672 · DOI: 10.5530/ijper.20251069 · 2025

   Background: Klebsiella pneumoniae is a ubiquitous opportunistic pathogen that poses a significant threat to hospitalized patients by causing a wide range of infections. The alarming increase in clinical resistance to all…

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3. The Effect of Kaempferol on Cortical Nlrp3/Caspase-1/Gsdmd Mediated Cell Pyroptosis in Chronic Epileptic Rats

   Guang Yang, Rui Cai

   pp. 673-681 · DOI: 10.5530/ijper.20250368 · 2025

   Aim: To study the Kaempferol (Kaem) on Pentetrazol (PTZ)-induced chronic epileptic rats, and to explore its effect on nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3)/ caspase-1/gasdermin D (GSDM…

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4. Network Pharmacology-Based Modeling of Phytocompounds in a Traditional Siddha Formulation-Kabasura kudineer with Special Reference to SARS-CoV-2

   Krishna Kant Gupta, Yatindrapravanan Narasimhan, Shashank Ravichandran, Brindha Pemaiah, Davidraj Chellappan, Ragothaman Madhava Rao Yennamalli, Sriram Sridharan

   pp. 682-694 · DOI: 10.5530/ijper.20256024 · 2025

   Background: Kabasurak kudineer (Kk), a traditional Siddha formulation containing 15 plant-based ingredients has been prescribed in Siddha medicine for the management and treatment of flu-like symptoms. Currently, the Min…

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5. Cardamonin Lowers Intraocular Pressure and Inhibits Glaucoma Development in Steroid-Induced Rats by Activation of Nrf-2/Ho-1 Pathway

   Yuan Fang, Li Meng, Ruifen Zhang

   pp. 695-703 · DOI: 10.5530/ijper.20250444 · 2025

   Background: Glaucoma, a progressive optic neuropathy characterized by optic nerve injury, is a pivotal cause of vision loss globally. Objectives: The current work focuses on assessing the therapeutic role of cardamonin a…

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6. Characterization and Evaluation of Antidiabetic Potentials of Plectranthus amboinicous-Derived Nanoparticles

   Shaeena MH, Bharathi D.R

   pp. 704-711 · DOI: 10.5530/ijper.20250571 · 2025

   Background: Plectranthus amboinicus (Lour.) Spreng, a member of the Lamiaceae family, is commonly utilized in both traditional medicine and culinary applications. This research focuses on optimizing the pharmacodynamic a…

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7. Research on the Path and Strategy of Traditional Chinese Medicine Talent Cultivation Based on Demand Orientation

   Shuhong Xu, Boyang Yu

   pp. 712-718 · DOI: 10.5530/ijper.20252630 · 2025

   Background: Traditional Chinese Medicine (TCM) has shown unique advantages in the prevention and treatment of chronic complex diseases, emergency treatment and major infectious diseases, especially COVID-19 epidemic. Ref…

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8. Eco-Friendly Fabrication of SnO2-Curcumin Nanoparticles via Pterocarpus marsupium Extract: Unveiling Potent Antimicrobial and Anticancer Applications

   Mohammed Albratty, Hafiz A Makeen

   pp. 719-726 · DOI: 10.5530/ijper.20257442 · 2025

   Background: Curcumin-SnO2 Nanoparticles (NPs) are advanced materials that combine organic molecules and inorganic substances in a single nanoscale platform to create hybrids with unique and enhanced properties. The syner…

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9. Anti-Arthritic Effect of Traditional Chinese Medicinal Compound Bavachalcone on Freund’s Complete Adjuvant-Induced Rheumatoid Arthritis in Rats

   Xinglei Xiao, Shanglun Liu, Guoqing Chen, Chen Cao

   pp. 727-737 · DOI: 10.5530/ijper.20257346 · 2025

   Background: Oxidative stress and inflammation are suggested to be the major etiological factors for the autoimmune disease rheumatoid arthritis. Rheumatoid arthritis affects millions of individuals all over the world eve…

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10. Antibacterial Activity of Bacteriocin-Like Inhibitory Substances Produced by Lactic Acid Bacteria Isolated from Cheese against Pathogens

    Amal Alghamdi, Kholoud Hesham, Shahad Alghamdi, Aya Kadi, Aeshah Aljohani, Amal Shori

    pp. 738-746 · DOI: 10.5530/ijper.20250239 · 2025

    Background: Lactic Acid Bacteria (LAB) produce bacteriocins, which have recently attracted considerable interest as alternatives to antibiotics. Cheese, a fermented food rich in LAB, is highly perishable and susceptible …

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11. Cardioprotective Role of Flavokawain A against Isoproterenol-Induced Acute Myocardial Infarction in Rats via Modulation of NF-?B/HO-1/NQO-1 Pathways

    Li Wu, Feizhang Qin, Chengcheng Zhao, Ping Hou

    pp. 747-756 · DOI: 10.5530/ijper.20257348 · 2025

    Background: Myocardial Infarction (MI) is a prevalent condition of heart disease. Despite remarkable growth in the treatment of heart diseases, MI remains the foremost cause of mortality worldwide and a significant patho…

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12. Chlorogenic Acid Functionalized Tin Oxide-Sodium Alginate Hybrid Nanomaterials Induce Oxidative Stress-Mediated Apoptosis in Breast Cancer MDA-MB-231 Cells

    Shakila Baby, Nouf M. Alyami, Hossam M. Aljawdah, Sulaiman Ali Alharbi, Palanisamy Arulselvan, Saravana Kumar Jaganathan, Samer Hasan Hussein-Al-Ali, Bharathi Muruganantham

    pp. 757-766 · DOI: 10.5530/ijper.20257391 · 2025

    Background: Nanotechnology has emerged as a novel research area to address the several problems associated with existing cancer treatments. Objectives: The present work was focused on synthesizing and characterizing the …

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13. Comparative Efficacy of Cytokines and Drugs in Promoting the Expansion of Bone Marrow-Derived Mesenchymal Stem Cells: A Systematic Review and Meta-Analysis

    Jinhui Liu, Sheng Liu, Chunming Li

    pp. 767-776 · DOI: 10.5530/ijper.20251689 · 2025

    Aim/Background: Bone Marrow (BM) Mesenchymal Stem Cells (MSCs) possess significant clinical potential, yet their limited expansion ability in the laboratory restricts their broad application. While cytokines and pharmace…

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14. Assessing the Cytotoxicity and Wound Healing Potential of Pranic Healing Colours: An in vitro Study on HaCaT Cell Line

    Srikanth Nagaraja Jois

    pp. 777-782 · DOI: 10.5530/ijper.20250945 · 2025

    Background: Pranic Healing is a complementary therapy that uses specific colours to enhance the healing of wounds. Objectives: Our research sought to investigate the impacts of integrating various Pranic Healing (PH) col…

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15. Isoliensinine Prevents against Lipopolysaccharide-induced Rat Acute Lung Injury and Sepsis via Inhibiting the Inflammatory Mediators

    Lili Gao, Jie Qi

    pp. 783-789 · DOI: 10.5530/ijper.20250460 · 2025

    Background: Novel pharmaceuticals have been largely derived from natural substances. Through this experimental study, we sought to assess the impacts of Isoliensinine (ILS) on Acute Lung Injury (ALI) and sepsis caused by…

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16. Thymol Improves Brain Functional Outcomes after Cerebral Ischemia-Reperfusion Injury by Regulating p38 MAPK Associated Apoptosis Signalling Pathway

    Hima Saila Mukkudiahgari, Ramesh Reddy Kudamala, Santhrani Thakur

    pp. 790-799 · DOI: 10.5530/ijper.20257027 · 2025

    Background: Thymol, a monoterpene phenolic compound and an essential oil extracted from Tachyspermum ammi (ajwain) has been shown to possess multiple therapeutic potentials as anti-inflammatory, antioxidant, antihyperlip…

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17. Pennogenin Induces Apoptosis in Colon Cancer HCT-116 Cells via Increasing Apoptotic Markers and Downregulating PI3K/AKT/mTOR Pathway

    Guangtao Zheng, Dan Gao, Lei Wang, Ke Zhou

    pp. 800-809 · DOI: 10.5530/ijper.20250474 · 2025

    Background: Colon cancer is the third major type of cancer globally and the second most reason for cancer-associated mortality. Natural products (phytochemicals) are considered safer alternatives to treat colon cancer. O…

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18. Investigating the Dual-Action Potential of (Z)-6-methoxy 2-(naphthalen-1-ylmethylene) Benzofuran-3(2H)-one (AU-23): A Novel Synthetic Aurone Derivative with Antibacterial and Anti-Inflammatory Activ

    Rabia Mrehil Elsalami, Kamal Rullah, Yaman Walid Kassab, Mohammad Javed Qureshi, Waqas Ahmad, Mahani Mahadi, Masriana Hassan, Noraziah Mohamad Zin, Anwar Salm Kalifa Kafo, Chin Chai Yee, Najwa Mohamad

    pp. 810-825 · DOI: 10.5530/ijper.20255518 · 2025

    Aim/Background: Aurone is a well-known, naturally occurring, minor flavonoid with significant biological properties. However, their low abundance in nature limits their application in the medical field. In this study, we…

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19. Application of Network Pharmacology, Computational Molecular Docking and Experimental Techniques to Study the Anticancer Effects of Ursolic Acid on Oral Squamous Carcinoma Cells

    Ling Zhu, Zhiyao Li, Jing Dong

    pp. 826-840 · DOI: 10.5530/ijper.20250379 · 2025

    Background: Oral Squamous Cell Carcinoma (OSCC) is a prevalent and aggressive form of cancer with limited effective therapeutic options. This study explores the potential anticancer effects of ursolic acid and its mechan…

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20. Quality by Design-Driven HPLC Method Development for Quantification of Resveratrol in Bulk and Pharmaceutical Dosage Form and its Validation

    Swati Devendra Raysing, Ashish Prakash Gorle

    pp. 841-848 · DOI: 10.5530/ijper.20254922 · 2025

    Background: The purpose of the recent research was to establish a simple, efficient, sensitive and accurate High-Performance Liquid Chromatography (HPLC) method for estimating Resveratrol (RVT) in bulk and pharmaceutical…

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