Eco-Friendly Fabrication of SnO2-Curcumin Nanoparticles via Pterocarpus marsupium Extract: Unveiling Potent Antimicrobial and Anticancer Applications

Indian Journal of Pharmaceutical Education and Research

  • Mohammed Albratty1Department of Pharmaceutical Chemistry and Pharmacognosy, College of Pharmacy, Jazan University, Jazan, SAUDI ARABIA.
  • Hafiz A Makeen2Department of Clinical Pharmacy, Pharmacy Practice Research Unit, College of Pharmacy, Jazan University, Jazan, SAUDI ARABIA.

Volume 59 Issue 2 Pages 719-726

DOI: 10.5530/ijper.20257442

Abstract

Background: Curcumin-SnO2 Nanoparticles (NPs) are advanced materials that combine organic molecules and inorganic substances in a single nanoscale platform to create hybrids with unique and enhanced properties. The synergy between the two components often results in improved functionality, stability and efficacy. Objectives: The current work was conducted on Curcumin-SnO2 NPs synthesized using an eco-friendly method with Pterocarpus marsupium extract and evaluated their antimicrobial and cytotoxic effects on MDA-MB-231 cancer cells. Materials and Methods: The synthesized Curcumin-SnO2 NPs were characterized using various methods, including XRD, SEM, PL and UV-visible spectroscopy analyses. The antimicrobial property of Curcumin-SnO2 NPs was assessed by the disc diffusion method against various pathogens. The cytotoxicity of Curcumin-SnO2 NPs on MDA-MB-231 cancer cells was assessed by a WST-1 assay. Results: Characterization of Curcumin-SnO2 NPs using X-ray Diffraction (XRD) revealed a tetragonal structure. Photoluminescence (PL) spectra ranging from 350 to 550 nm indicated the presence of tin and oxygen vacancies (surface defects). The Curcumin-SnO2 NPs exhibited higher antimicrobial activity against Bacillus megaterium, Klebsiella pneumoniae and Candida albicans than conventional antibiotics. The Curcumin-SnO2 NPs effectively inhibited the viability of breast cancer cells. Conclusion: These findings suggest the potential use of Curcumin-SnO2 NPs in healthcare institutions to improve patient outcomes.

Keywords

  • Curcumin
  • Nanoparticles
  • Pterocarpus Marsupium
  • MDA-MB-231 cancer cells.
IJOPP

Loading…