Table of Contents

Original Article(continued)

1. Formulation and in-vitro Evaluation of Oral Captopril Bioadhesive Delivery System

   Mohamed Dawoud, Fahima Hashem

   pp. s200-s209 · DOI: 10.5530/ijper.54.2s.76 · 2020

   Background: Captopril is considered as the drug of choice in the treatment of hypertension and congestive heart failure. It has a very short duration of action and a biological half-life of 1-2 hr. This requires its admi…

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2. Xyloglucan Based Nasal in situ Gel Formulation of Mirtazapine for Treatment of Depression

   Wadetwar Rita Naresh, Deshmukh Vaibhav Dilip, Kanojiya Pranita Sunil

   pp. s210-s219 · DOI: 10.5530/ijper.54.2s.77 · 2020

   Objectives: The objective of the present work was formulation of thermosensitive mucoadhesive in situ nasal gel of Mirtazapine for depression. The nasal route would overcome the first-pass effect and would enhance its ef…

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3. Supramolecular Complexes of Phospholipids and β-Cyclodextrin with Bioactive β-Carotene: A Comparative Physico-Chemical and Functional Evaluation

   Saurabh Gujar, Darshan Telange, Anil Pethe

   pp. s220-s229 · DOI: 10.5530/ijper.54.2s.78 · 2020

   Background: β-carotene, a chief component of carotenoids family exhibits multiple numbers of pharmacological activities. However, its poor aqueous solubility and low dissolution rate restricts it to become a potential dr…

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4. Tenofovir Loaded Poly (Lactide-Co-Glycolide) Nanocapsules: Formulation Optimization by Desirability Functions Approach

   Grandhi Srikar, Avula Prameela Rani

   pp. s230-s240 · DOI: 10.5530/ijper.54.2s.79 · 2020

   Background: Nanoparticles made of biodegradable polymers are the most effective colloidal drug delivery systems. The in vitro characteristics as well as in vivo presentation of these nanoparticles are majorly influenced …

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5. Comparison of Release Retardant Effect of Some Novel Lipids by Formulating Sustained Release Tablet of BCS Class 1 Drug

   Rajni Devi, Ram Babu Sharma, Abhishek Sharma, Shweta Agarwal

   pp. s241-s250 · DOI: 10.5530/ijper.54.2s.80 · 2020

   Aim: The study was carried out with the objective of comparing the release retardant effect of some novel lipids by preparing sustained release tablets of highly watersoluble drug, theophylline. Methods: The tablets were…

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6. In vitro Anthelmintic Impact of Various Extracts of Pavetta tomentosa Root on Pheretima posthuma and in-silico Molecular Docking Evaluation of some Isolated Phytoconstituents

   Dintakurthi Sree Naga Bala Krishna Prasanth, Siva Prasad Panda, Atmakuri Lakshmana Rao, Nayudu Teja, Veenam Bhavya Naga Vani, Tera Sandhya, Pathange Bharghava Bhushan Rao

   pp. s251-s260 · DOI: 10.5530/ijper.54.2s.81 · 2020

   Background: The current study assesses the anthelmintic impact of root extracts of Pavetta tomentosa on Pheretima posthuma compiled by molecular docking analysis of phytocompounds steemed from the plant with the β-Tubuli…

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7. In-vivo Screening of Ethanolic Extract of Antigonon leptopus Flower for Anti-diabetic and Antioxidant Potential

   Satish Annayya Kavatagimath, Sunil Satyapa Jalalpure, Ravindra Durdundayya Hiremath, Amolkumar Ashok Kempwade

   pp. s261-s268 · DOI: 10.5530/ijper.54.2s.82 · 2020

   Objectives: Medicinal plants have always been a consummate source for drugs and already provided us with lead compounds for numerous currently available drugs with no or less side effects. This supports the usage of herb…

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8. Antifungal Nail Lacquer Loaded with Extract of Cissus quadrangularis for Treatment of Onychomycosis

   Ashlesha Pravin Pandit, Amarnath Arunrao Kedar, Suvidya Vilas Ranaware, Kishanchandra Radheshyam Khandelwal

   pp. s269-s276 · DOI: 10.5530/ijper.54.2s.83 · 2020

   Objectives: An attempt was made to prepare transparent nail lacquer containing natural antifungal agent obtained from extract of whole plant of Cissus quadrangularis for the treatment of onychomycosis. Methods: The extra…

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9. Effect of Gymnema sylvestre on Insulin Receptor (IR) and Proglucagon Gene Expression in Streptozotocin Induced Diabetic Rats

   Eswar Kumar Kilari, Swathi Putta, Kotaiah Silakabattini

   pp. s277-s284 · DOI: 10.5530/ijper.54.2s.84 · 2020

   Aim: To study the expression of Insulin Receptor (IR) in pancreas and proglucagon in the ileum homogenate with the hydroalcoholic extract of Gymnema sylvestre (HAGS) in streptozotocin induced diabetic rats. Materials and…

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10. Neuroprotective Effects of Licorice Extracts in Tibial and Sural Transection Induced Neuropathic Pain in Rats

    Tanmayee Amit Joshi, Pratima Tatke

    pp. s285-s294 · DOI: 10.5530/ijper.54.2s.85 · 2020

    Background: Neuropathic pain (NP) is the worst of tortures, a nerve wound may experience as a result of nerve damage or complication of diabetes/HIV/cancer. There are no defined guidelines for treatment. Available treatm…

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11. In-vitro Cytotoxicity and in silico Molecular Docking of Alkaloids from Tiliacora acuminata

    Jeswiny Rodrigues, Kirankumar Hullatti, Sunil Jalalpure, Pukar Khanal

    pp. s295-s300 · DOI: 10.5530/ijper.54.2s.86 · 2020

    Background: The present study aimed to identify the cytotoxicity of Tiliacora acuminata extract/fraction(s) plant via bioactivity guided approach and predict the binding affinity with Topoisomerase II. Materials and Meth…

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12. Bioassay-Guided Fractionation of Endophytic Fungal Extract of Fusarium solani (Saccardo) against Cancer Cell Lines and Zebrafish Embryo

    Nael Mahmoud Abutaha, Muhammed Farooq Farooq, Fahd Ali Nasr, Fahd Abdu Ahmed Almekhlafi, Muhammad Wadaan

    pp. s301-s308 · DOI: 10.5530/ijper.54.2s.87 · 2020

    Background: This study aimed to explore the toxicity and apoptotic potential of Fusarium solani extracts on cancer cell lines and zebrafish embryo. Materials and Methods: F. solani was initially extracted with ethyl acet…

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13. New Bioactive Molecules Isolated for the First Time from Hyoscyamus albus L. and their Mechanisms Underlying the Anticancer Effects

    Massinissa Yahia, Afaf Benhouda, Mouloud Yahia, Hamada Haba, Francisco Campos, Souhila Benbia, Antonio Rangel

    pp. s309-s315 · DOI: 10.5530/ijper.54.2s.88 · 2020

    Background: Hyoscyamus albus L is a small genus from Solanaceae family known by its use in old traditional medicine in the east of Algeria. Aim: This study aimed to characterize new bioactive molecules from H. albus, eva…

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14. Structural Elucidation of Isolated Phytochemicals from Selected Medicinal Plants with Antihyperlipidemic Activity and Development of Polyherbal Formulation with Densitometric Analysis of Isolated Phytoconstituents

    Deepa Iyer, Umesh K Patil

    pp. s316-s329 · DOI: 10.5530/ijper.54.2s.89 · 2020

    Objectives: The present systematic research aimed to express the antihyperlipidemic effects of different types of herbs based on animal studies. The purpose of the present project is to perform the phytochemical investig…

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15. Total Synthesis of Clausenain, a Cyclic Octapeptide and its Analog for Anticancer Activity

    Nirmala Shinde, Avinash Shridhar Dhake, Kishan Prabhu Haval, Sachin Kawaduji Bhosale

    pp. s330-s336 · DOI: 10.5530/ijper.54.2s.90 · 2020

    Keeping in mind requisite of today’s era for development of new anticancer drugs, synthesis of a phenyl alanine rich cyclic octapeptide Clausenain and its analog by solution phase technique is described here. It was done…

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16. Ultraviolet-visible Spectrophotometric Method for Estimation of Gliclazide in Presence of Excipients Interacting in UV-visible Region

    Neelkant Prasad, Aditya Sharma

    pp. s337-s343 · DOI: 10.5530/ijper.54.2s.91 · 2020

    A simple and sensitive ultraviolet spectrophotometric method for quantitative estimation of a model API gliclazide in presence of excipients is described to avoid false estimation due to presence of soluble or insoluble …

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17. Stability Indicating RP-HPLC Method Development and Validation for the Quantification of Obeticholic Acid in Bulk and its Pharmaceutical Dosage Form

    R. Kiran Jyothi, K.B. Chandrasekhar, M. Balakrishnan, B. Siva Sai Kiran

    pp. s344-s349 · DOI: 10.5530/ijper.54.2s.92 · 2020

    Aim and Objectives: The aim of present research work is to develop stability indicating validated RP-HPLC method for the quantification of Obeticholic acid in bulk and its pharmaceutical dosage form. Materials and Method…

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18. Development and Validation of Novel Stability- Indicating LC Method for the Determination of Saxagliptin and Metformin

    Sachin Bhanudas Gurav, Neela Manish Bhatia

    pp. s350-s357 · DOI: 10.5530/ijper.54.2s.93 · 2020

    Aim: Development of a novel precise, selective and sensitive stability indicating RPHPLC method has been developed and validated for the determination of Saxagliptin hydrochloride (SAX) and Metformin HCl (MET) in bulk dr…

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19. Development and Validation of a Simultaneous Bioanalytical Method for Methotrexate, Sulfasalazine and Hydroxychloroquine in Rat Plasma following Single Step Protein Precipitation Technique

    Pichili Ajitha Reddy, Amit Kumar Sahu, Manish Kumar Sharma, Pinaki Sengupta

    pp. s358-s367 · DOI: 10.5530/ijper.54.2s.94 · 2020

    Background: Triple therapy of methotrexate, sulfasalazine and hydroxychloroquine is widely used in the treatment of rheumatoid arthritis. Different studies reported the superior efficacy of combination of these three dru…

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20. Simultaneous RP-HPLC Quantification of Four Phenolics in Elephantopus scaber L. and their in vitro Pharmacological Validation

    Pushpendra Kumar Shukla, Ankita Misra, Bhanu Kumar, Abhishek Niranjan, Sharad Srivastava

    pp. s368-s373 · DOI: 10.5530/ijper.54.2s.95 · 2020

    Elephantopus scaber (L.) is a widely used traditional medicinal plant, grows in hotter parts of the Indian subcontinent, Tropical Africa and East Asia. The present study was aimed RPHPLC quantification of phenolics and i…

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