A Comprehensive QbD Study on Bioadhesive Ocular Films for Improved Conjunctivitis Management: Insights from Design Expert Software

Indian Journal of Pharmaceutical Education and Research

  • Repollu Maddileti1Department of Pharmaceutical Sciences, Jawaharlal Nehru Technological University-Anantapur, Ananthapuram, Andhra Pradesh, INDIA.
  • Haranath Chinthaginjala2Department of Pharmaceutics, Raghavendra Institute of Pharmaceutical Education and Research (Autonomous), KR. Palli Cross, (Affiliated to JNTU-Anantapur), Ananthapuram, Andhra Pradesh, INDIA.

Volume 59 Issue 1 Pages 122-133

DOI: 10.5530/ijper.20255680

Abstract

Objectives: The study aimed to develop ocular films containing levofloxacin to treat conjunctivitis. These films were meticulously prepared using a combination of Gelatin, Aloe barbadensis leaves mucilage, and HPMC K4M, by the solvent casting technique, with the primary objective of enhancing the therapeutic efficacy of levofloxacin for this specific eye condition. Materials and Methods: A comprehensive evaluation was carried out to ensure the quality and reliability of the films, encompassing parameters such as film thickness, weight variation, content uniformity, percentage moisture loss, and absorption capacity. In addition, in vitro drug release studies were conducted to simulate the eye's conditions and understand the controlled release of the drug. The study also considered the influence of polymer concentrations, on drug release using Design Expert software’s Box Behnken Design. Results: Notably, the research revealed that the ocular films followed zero-order kinetics, meaning they released the drug at a constant rate over time. Conclusion: Furthermore, the films demonstrated stability under ambient conditions, making them a promising alternative for prolonged drug delivery and improved therapeutic outcomes in conjunctivitis treatment.

Keywords

  • Biodegradable
  • Eye
  • Film
  • Levofloxacin
  • Ocular
IJOPP

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