Acetyl-11-Keto-β-Boswellic Acid-Loaded Ethosomes as Nanocarriers from a Physicochemical Perspective and in vivo Evaluation

Indian Journal of Pharmaceutical Education and Research

  • Daphisha Marbaniang1Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, INDIA.
  • Niva Rani Gogoi1Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, INDIA.
  • Paulami Pal1Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, INDIA.
  • Anup Kumar Das2Department of Pharmaceutical Sciences, Assam University, Silchar, Assam, INDIA.
  • Bani Kumar Jana1Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, INDIA.
  • Ananta Saikia3Department of Pharmaceutical Sciences, Pratiksha Institute of Pharmaceutical Sciences, Panikhaiti, Assam, INDIA.
  • Bhaskar Mazumder

Volume 59 Issue 1 Pages 82-93

DOI: 10.5530/ijper.20254420

Abstract

Background: Ethosomes are elastic nanovesicles made of phospholipids that contain a high concentration of ethanol. It has shown to improve the skin permeability of many drugs due to interactions between the high ethanol. Materials and Methods: The optimization and characterization of 3-Acetyl-11-Keto-β-Boswellic Acid (AKBA) loaded vesicular ethosomes included measurements of particle size, entrapment effectiveness, microscopy using SEM and TEM, and the interaction of the drug and excipients using Fourier transform infrared spectroscopy was carried out. FT-IR studies revealed no interaction between the drug and the excipients. Additionally, in vitro drug permeation test utilizing pig ear skin was conducted on ethosomal formulations. E8 (containing 30% alcohol, 2% w/w phospholipid), was chosen for additional skin permeation studies due to its high percentage of drug entrapment (88.43%) and small particle size (129.3±0.75nm). Results: The formulation E8 had the greatest amount of drug permeability (73.22%). Furthermore, paw oedema assay using carrageenan induction was used to investigate the in vivo evaluation of the produced formulation. The anti-inflammatory efficiency of ethosomal vesicles containing AKBA was compared to that of AKBA-loaded carbopol gel. Conclusion: It revealed that ethosomal had higher anti-inflammatory activity than carbopol gel formulation. Our findings suggest that the developed ethosomal system has the potential to deliver AKBA through the skin.

Keywords

  • Ethosomes
  • Transdermal flux
  • Acetyl-11-keto-beta-boswellic acid
  • Lipid-based vesicles
  • Permeation enhancers
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