Table of Contents

Original Article(continued)

1. Phytochemical Screening, HPTLC Finger Print and in vitro Antioxidant Activity of Bark Extracts of Lannea coromandelica (Houtt.) Merr.

   Rajesh. R

   pp. 498-506 · DOI: 10.5530/ijper.55.2.88 · 2021

   Background: Lannea coromandelica Merr (Houtt.) is used as a common medicinal plant among the tribal communities of Bangladesh has long been used in indigenous medicine for curing certain health disorders. Phytochemicals …

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2. Anti-inflammatory and Anti-arthritic Activity of Rosmarinic acid Isolated from Rosmarinus officinalis in an Experimental Model of Arthritis

   Tianhu Wei, Yuan Liu, Meirong Li

   pp. 507-516 · DOI: 10.5530/ijper.55.2.89 · 2021

   Background: Rosmarinus officinalis L. (family Lamiaceae is a perennial herb or small woody evergreen tree, commonly known as rosemary, which is native to the Mediterranean and Asia and reasonably hardy in cool climates. …

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3. Therapeutic Phytochemical Actives for Potential Control of SARS-CoV-2

   Dipjyoti Dey, Nirban Dey, Shalini Ghosh, Imran Khan, Padma Thiagarajan

   pp. 517-526 · DOI: 10.5530/ijper.55.2.90 · 2021

   Background: Drug development strategies for treating COVID-19 focus on actives that either physically block angiotensin-converting enzyme-2 (ACE-2) receptors (viral entry point), or those, which inactivate viral protease…

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4. Adjunction of the Lipase Inhibitor Orlistat Improves Grape Seed Extract Neuroprotection against Brain Ischemia/Reperfusion Injury in Rats

   Slim Ghrir, Wassim Ben Abbes, Kamel Charradi, Salem Elkahoui, Ferid Limam, Ezzedine Aouani

   pp. 527-543 · DOI: 10.5530/ijper.55.2.91 · 2021

   Aim: Stroke is a public health concern for which there is currently no prophylaxis. In this study, we assessed the protective effect of Grape Seed Extract (GSE) and Orlistat (ORL) against brain ischemia/reperfusion (I/R)…

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5. Investigation of the Effects of Calcium Fructoborate on Testicular Structure in Rats within the Framework of Biochemical Parameters, Testosterone Hormone and DNA Damage in Cadmium Chloride Induced Toxicity

   Saadet Belhan, Ahmet Ufuk Kömüroğlu, Uğur Özdek, Ali Sefa Mendil, Ali Rıza Kul, Muhammed Bahaeddin Dörtbudak, Arzu Gezer

   pp. 544-549 · DOI: 10.5530/ijper.55.2.92 · 2021

   Background: The present study aims to investigate the effects of calcium fructoborate on testicular DNA damage and testicular tissue biochemical markers and serum testosterone levels after cadmium chloride administration…

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6. Punicalagin Suppresses LPS-induced Inflammatory Responses in Murine Macrophages via JAK/STAT Signaling Pathway and Zymosan-induced Mice Paw Edema

   Huan Yan, Abilaiti Gulimire, Junyu Zhu, Huaping Liang, Zhengyi Gu

   pp. 550-555 · DOI: 10.5530/ijper.55.2.93 · 2021

   Aim: To investigate the anti-inflammatory activity of punicalagin (PUN) on mouse macrophages and the underlying mechanisms. Materials and Methods: Mouse primary peritoneal macrophages (PMs) were treated with lipopolysacc…

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7. Lyophilized Fruit Juice of Citrus sinensis Triggers Mitochondria-mediated Apoptosis via Downregulation of PI3K/AKT in MCF-7 Cell Line

   Jayasindu Mathiyazhagan, John Arul Daniel, George Priya C. Doss, Rama Jayaraj, Kodiveri Muthukaliannan Gothandam

   pp. 556-565 · DOI: 10.5530/ijper.55.2.94 · 2021

   Background: Breast cancer is prevalent cancer among women and a major cause of death worldwide due to various genetic and environmental factors. Citrus sinensis is widely taken fruit juice in most countries that are beli…

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8. Antiproliferative and Apoptotic Induction of Allicin in Human Lung Cancer Cell Lines

   Zeenath Vadakkenchery Mohammed Hussain, Santhy Kumaran Sivanandhan

   pp. 566-573 · DOI: 10.5530/ijper.55.2.95 · 2021

   Background: The study relied on exploring the anticancer effects of allicin and the experimental parameters to scientifically prove its potential as a natural anticancer agent, condiment and dietary supplement present in…

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9. Synthesis, Antidiabetic Evaluation and Bioisosteric Modification of Quinoline Incorporated 2-pyrazoline Derivatives

   Abhishek Kumar, Pankaj Kumar, Chaithra Raju Shetty, Jainey Puthenveettil James, Honey Chandrashekhar Shetty

   pp. 574-580 · DOI: 10.5530/ijper.55.2.96 · 2021

   Background: Diabetes mellitus is a pervasive illness worldwide with many progressively increasing complications day by day. The quinoline nucleus is important heterocyclic moiety with different biological activities. Due…

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10. Designing of Thiazolidin-4-one Pharmacophore using QSAR Studies for Anti-HIV Activity

    Trupti Sameer Chitre, Shital Manoj Patil, Anagha Govindrao Sujalegaonkar, Kalyani Dhirendra Asgaonkar

    pp. 581-589 · DOI: 10.5530/ijper.55.2.97 · 2021

    Background and Aim: In an effort of drug development in the area of HIV, present work deals with development of 2D and 3D QSAR of thiazolidinone derivatives against HIV-RT activity as a powerful method for elucidation th…

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11. Development and Validation of Stability Indicating UV-Spectrophotometric Method for the Simultaneous Estimation of Telmisartan and Metformin Hydrochloride in Bulk Drugs

    Tirodkar Chaitali Uday, Palled Mahesh Shivabasappa, Shailendra Suryawanshi Sanjay

    pp. 590-597 · DOI: 10.5530/ijper.55.2.98 · 2021

    Background: In present work attempt has been made to develop and validate a simple and sensitive UV spectrophotometric method for simultaneous estimation of Telmisartan and Metformin Hydrochloride. Objectives: To develop…

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12. RP-HPLC Accelerated Degradation Method Development and Validation for Determination of Amlodipine and Atorvastatin in Combination Dosage Form of Tablet

    Anuruddha Rajaram Chabukswar, Pramod Hindurao Sakpal

    pp. 598-606 · DOI: 10.5530/ijper.55.2.99 · 2021

    Aim: The Cost effective, Accurate, Precise Accelerated degradation method has been developed for determination of Atorvastatin and Amlodipine in combination dosage form of tablet and validated as directed by ICH guidelin…

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13. Stability Indicating Assay Method Development and Validation for Simultaneous Estimation of Ofloxacin and Ornidazole by RP-HPLC in Bulk: An Application to Tablet Formulation and Dissolution Studies

    Kevita D’Souza, Alisha Syeda, Parnika Khatal, Muddukrishna Badamane Sathyanarayana, Vasantharaju SG

    pp. 607-613 · DOI: 10.5530/ijper.55.2.100 · 2021

    Aim: The present article focuses on development of sensitive, simple, precise, accurate and inexpensive stability indicating assay method for the simultaneous estimation of Ofloxacin and Ornidazole in bulk was establishe…

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14. Rapid Purification of Drug Enantiomers using Supercritical Fluid Chromatographic Method: Ibuprofen as a Model Compound

    Hwa Jong Lee, Jasper Gahm, Jong Sung Jin, Yun Gyong Ahn

    pp. 614-620 · DOI: 10.5530/ijper.55.2.101 · 2021

    Background: The purification of drug enantiomers is an essential technique because pharmacological activity differs depending on individual enantiomers. Nowadays, supercritical fluid technology is utilized for various pu…

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15. Results of Development and Application of an Objective Structured Clinical Examination: A Pioneering Experience in Pharmaceutical Care

    Maria Jose Zarzuelo, Maria Isabel Valverde-Merino, Maria Fernandez-Rodriguez, Noelia Amador-Fernandez, Alberto Uribe-Sanchez, Manuel Gomez-Guzman, Fernando Martinez-Martinez

    pp. 621-628 · DOI: 10.5530/ijper.55.2.102 · 2021

    Objectives: Objective Structured Clinical Examination (OSCE) is a tool to assess skills and competencies and it can be relevant in Pharmacy studies and more specifically in Pharmaceutical Care (PC) to develop more practi…

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16. Pharmaceutical Camel Products; Marketing Strategies for Successful International Penetration

    Meqbel Aliedan, Mansour Alyahya, Sneha Dhruvakumar, Nagaraja Sreeharsha, Santosh Fattepur

    pp. 629-637 · DOI: 10.5530/ijper.55.2.67 · 2021

    Background: This research aimed at how Saudi Arabia can be the global giant producer of pharmaceutical camel products using strategies for successful international penetration. In certain areas of Asia and Africa camel m…

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