Home | Articles
Published on:August 2019
Indian Journal of Pharmaceutical Education and Research, 2019; 53(3s):s239-s245
Original Article | doi:10.5530/ijper.53.3s.93

An Innovative Approach in Developing Sustained Release Matrix Tablets using Isolated and Characterized Novel Ceasalpinia sappan L. Seed Galactomannan

Authors and affiliation (s):

Shan Mohanan1,*, Sajan Jose2

1Department of Pharmaceutics, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS-Ponekkara, Kochi, Kerala, INDIA.

2University College of Pharmacy, Mahatma Gandhi University, Cheruvandoor Campus, Ettumanoor, Kerala, INDIA.


Introduction: The aim of the study is to develop a galactomannan-based drug delivery system. In this work galactomannan, a biocompatible polymer was isolated from a novel plant source. The seeds of the indigenous plant Caesalpinia sappan L. of the family Caesalpiniaceae were used for the extraction of galactomannan. Materials and Methods: The galactomannan was extracted by maceration and then purified. The purified polymer was characterized by physicochemical methods, FTIR studies, DSC study, SEM, thixotropic studies, microbial load and cytotoxic studies. In order to demonstrate its sustained release character a tablet formulation was prepared and propranalol was used as the model drug. The tablets were evaluated. The data obtained from in in-vitro drug release were fitted into different drug release models and the mechanism of drug release was determined. Results and Discussion: The FTIR studies of the isolated galactomannan revealed the presence of specific peaks for galactose, mannose and for glycosidic bonds. The DSC study showed a peak at 115ºC. The flow curve resulted in a pseudoplastic flow which is suitable for controlled drug delivery. A 72% recovery from sol to gel form was observed in the thixotropic studies. Cytotoxicity study proved the safety of the polymer and microbial load was found to be within the accepted limit. Sustained release property is demonstrated by formulating a matrix tablet of propranolol HCl using the isolated polymer. The formulated tablets complied with all the evaluation tests. The drug release pattern for about 16 hr was obtained through in vitro dissolution testing and the release mechanism was found to be fitting to Korsmeyer Peppa’s model. Conclusion: Galactomannan was successfully isolated and purified from Caesalpinia sappan seed and all the properties have been studied extensively. Galactomannan isolated from Caesalpinia sappan L seed can be used as an excellent pharmaceutical excipient for the formulation of matrix tablets.

Key words: Caesalpinia sappan, Galactomannan, Sustained drug release, Rheology, Thixotropy, Gum, Herbal formulation.



Impact Factor

IJPER - An Official Publication of Association of Pharmaceutical Teachers of India is pleased to announce continued growth in the 2019 Release of Journal Citation Reports (source: 2018 Web of Science Data).


Impact Factor® as reported in the 2018 Journal Citation Reports® (Clarivate Analytics, 2019): 0.425

User login

The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.


IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs