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Published on:August 2019
Indian Journal of Pharmaceutical Education and Research, 2019; 53(3s):s231-s238
Original Article | doi:10.5530/ijper.53.3s.92

Solubility Augmentation of Simvastatin by using the Marvelous Carrier Hydroxy Propyl beta-cyclodextrin: Compatibility Study, Statistical and Spectral Analysis


Authors and affiliation (s):

Disha Kesharwani1,*, Sandhya Mishra1, Swarnali Das Paul2, Rishi Paliwal3, Trilochan Satapathy1

1Columbia Institute of Pharmacy, Raipur, Chhattisgarh, INDIA.

2Faculty of Pharmaceutical Sciences, SSTC, SSGI, Bhilai, Chhattisgarh, INDIA.

3Faculty of Pharmacy, IGNTU, Amarkantak, Madhya Pradesh, INDIA.

Abstract:

Objective: The poor solubility which causes the poor bioavailability of simvastatin is an arduous task for the preparation of oral dosage form, which can be increased by the preparation of solid dispersion. Materials and Methods: The solid dispersions of simvastatin were prepared in different ratios by physical mixture method, kneading method and melting method using PEG 6000, β-cyclodextrin and Hydroxy Propyl β-cyclodextrin to enhance the solubility of poorly soluble drug. Results: These solid dispersions were analyzed for the solubility by prescribed methods. The solid dispersion of drug with HP β-cyclodextrin in 1:1 ratio has shown enormously improved solubility. Further FTIR and X-Ray studies were carried out. The compatibility study showed that there is no interaction between the drug and HP β-cyclodextrin and PXRD confirmed the amorphization of crystalline drug. Conclusion: The overall result showed that the solid dispersion of simvastatin can be prepared by various methods, of which the kneading method was best with HP β-CD in 1:1 (drug: polymer) ratio, in comparison with melting and physical mixture method. Hence we can conclude that the solubility of simvastatin can be enhanced using HP β-CD.

Key words: Solid dispersion, HP β-cyclodextrin, PXRD, HMG Co A reductase, Complexation.

 

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IJPER - An Official Publication of Association of Pharmaceutical Teachers of India is pleased to announce continued growth in the 2019 Release of Journal Citation Reports (source: 2018 Web of Science Data).

 

Impact Factor® as reported in the 2018 Journal Citation Reports® (Clarivate Analytics, 2019): 0.425

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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