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Published on:August 2019
Indian Journal of Pharmaceutical Education and Research, 2019; 53(3s):s246-s254
Original Article | doi:10.5530/ijper.53.3s.94

Extended Release Floating Microballoons Containing Clerodendrum colebrookianum Extract: in vitro in vivo Evaluation


Authors and affiliation (s):

Daphisha Marbaniang1,*, Ratna Jyoti Das1, Paulami Pal1, Ananta Saikia2, Manash Pratim Pathak1,3, Santa Mandal3,4, Nilutpal Sharma Bora1,3, Anup Kumar Das5, Pronobesh Chattopadhyay3, Subhabrata Ray6, Bhaskar Mazumder1

1Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, INDIA.

2Pratiksha Institute of Pharmaceutical Sciences, Panikhaiti, Assam, INDIA.

3Division of Pharmaceutical Technology, Defence Research Laboratory, Tezpur, Assam, INDIA.

4School of Pharmaceutical Sciences, IFTM University, Moradabad, Uttar Pradesh, INDIA.

5Department of Pharmaceutical Technology, Adamas University, Barasat, West Bengal, INDIA.

6Dr. B.C.Roy College of Pharmacy and Allied Health Sciences, Bidhan Nagar, Durgapur, West Bengal, INDIA.

Abstract:

Aims: Microballoons are floating particulate system comprising of a hollow core, drug being loaded within the polymeric layer. The aim of the study was to prepare microballoons containing extract of Clerodendrum colebrokianum, as bioactive agent. Methods: The microballoons were prepared by solvent diffusion technique, prepared microballoons were physico-chemically characterized (Scanning Electron Microscopy (SEM), buoyancy determination, entrapment efficiency, etc), in vitro drug release study and estimated for its in vivo antihypertensive activity by 2K1C hypertension induction method. Results: SEM confirmed the microballoons to be spherical with porous surfaces and hollow core. The developed formulation showed a buoyancy varying from 70.18%-89.90%. The entrapment efficiency of bioactives in microballoons was found between 52%-69% with a delayed release of maximum 28% in 8 hr as found from in vitro drug release study. In vivo antihypertensive studies carried out in rat model showed C. colebrookianum extract have good antihypertensive activity in both high and low dose with respect to standard propanolol. The formulations containing both doses were further found to be effectual in the treatment of hypertension because of its floating nature. Conclusion: The results suggested that optimized formulation show an effective extended release of Clerodendrum colebrokianum extract for the treatment of hypertension.

Key words: Microballoons, Antihypertensive agent, Encapsulation, Floating drug delivery system, 2K1C hypertension induction method.

 

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IJPER - An Official Publication of Association of Pharmaceutical Teachers of India is pleased to announce continued growth in the 2019 Release of Journal Citation Reports (source: 2018 Web of Science Data).

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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