Design and Development of Chitosan-Based Posaconazole Loaded Dry Powder by Using BBD

Indian Journal of Pharmaceutical Education and Research

  • Sushil Kumar Singh1Department of Pharmaceutical Technology, Ganpat University, Kherva, Mehsana, Gujarat, INDIA.
  • Shyam Sunder Pancholi2Department of Pharmaceutics, School of Pharmacy and Technology Management (SPTM) SVKM’s NMIMS (Deemed to be University) Mukesh Patel Technology Park, Babulde, Shirpur, Dhule, Maharashtra, INDIA.

Volume 60 Issue 2s Pages s443-s461

DOI: 10.5530/ijper.20261364

Abstract

Aim: Quality by Design (QbD)-Optimized Spray-Dried Microparticles (prepared by using spray drying process) of Posaconazole-Loaded Chitosan Nanoparticles (POS-CSNPs) for enhanced antifungal efficacy. Materials and Methods: Box-Behnken Design (BBD) a systematic design of experiments was implemented, to screen and optimize the formulation variables for the intended qualities. Results: Outcomes showed that POS-CSNPs have particle size (259.33±6.82 nm), Poly dispersity Index (0.192±0.010), zeta potential (-31.23±0.84 mV) and %Entrapment Efficiency (65.17±1.71). In vitro fungal study result showed the enhanced antifungal and higher fungicidal effect on Rhizopus oryzae strains. Conclusion: From the result it is concluded that the preparation of POS-CSNPs have higher anti-fungal effect on fungus strain.

Keywords

  • Box-Behnken design
  • Dry powder Inhaler
  • In vitro Fungal study
  • Nanoparticles
  • Posaconazole
IJOPP

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