Volume 60, Issue 5 (KrupaPharmaCon 2026)

Dipan Sundar Dash, Vinni Kalra, Ashif Keloth Thazhe Kuniyil, Amit Tanaji Dalave, Pranab Moudgil

pp. 1-8 · DOI: 10.5530/ijper.krupapharmacon.19 · 2026

The Committee for Medicinal Products for Human Use (CHMP) at EMA issues scientific guidelines to assist applicants. A variations regulation, made effective in 2008 to govern post-authorization changes, was last updated i…

K Selvakumar, PV Kavya, Shirisha R, Joysa Ruby J

pp. 9-26 · DOI: 10.5530/ijper.krupapharmacon.20 · 2026

Background: The pharmaceutical industry is undergoing rapid digital transformation through the adoption of advanced technologies aimed at improving operational efficiency, product quality, regulatory compliance, and supp…

Nimisha Jain, Preeti Sudheer, M Madhan Madhan, Anjitha C J

pp. 27-41 · DOI: 10.5530/ijper.krupapharmacon.21 · 2026

Background: Meloxicam is a BCS Class Ⅱ NSAID, with gastrointestinal side effects and shows poor skin permeability when administered orally. Nanostructured Lipid Carriers (NLC), consisting of both solid and liquid lipids,…

Nithyasri Jayavel, Deepika Tammineni, Eswar Gupta Maddi

pp. 42-53 · DOI: 10.5530/ijper.krupapharmacon.22 · 2026

Background: Periodontitis is a chronic inflammatory disease associated with bacterial plaque accumulation, and its treatment is often limited by the inadequate retention of antimicrobial agents within periodontal pockets…

Milind P. Wagh, Supriya B. Sandhan, Piyusha M. Patil

pp. 54-65 · DOI: 10.5530/ijper.krupapharmacon.23 · 2026

Objectives: Rosuvastatin calcium is crystalline, BCS Class II drug having low solubility and bioavailability approximately 20%. Crystalline nature of drug result in poor dissolution, flowability, and compressibility, whi…

Manjunatha Gooranahalli Ravikumar, Panner Selvam Raju, Prajwal Bangalore Venkatesh

pp. 66-75 · DOI: 10.5530/ijper.krupapharmacon.24 · 2026

Background: Meclizine hydrochloride Solid Self-Nanoemulsifying Drug Delivery System S-SNEDDS) was formulated and optimized to improve solubility and intestinal absorption. Objectives: Solubility studies identified Transc…

M. Christina Balapriya, Raman Dang, Beulah Milton, Ravikumar, Mahesh Basanagauda Mudhol

pp. 76-83 · DOI: 10.5530/ijper.krupapharmacon.25 · 2026

Background: Knee osteoarthritis is a relatively common degenerative joint disorder in the world and one of the leading reasons behind chronic pain, disability, and impaired quality of life among the elderly population. D…

Girinath Murali, Sushmitha Narayanappa, Makeshwar Periya Samy, Sangeetha Govindarajan

pp. 84-99 · DOI: 10.5530/ijper.krupapharmacon.26 · 2026

Objectives: Oxaprozin is a propionic acid derivative belonging to the Non-Steroidal Ant-Inflammatory Drug (NSAID) class, used to treat inflammation and pain in musculoskeletal conditions. Oral administration of Oxaprozin…

Prabhu Bellure, Pragathi Vijayadev, Kavitha Arenur Narayan Ready

pp. 100-111 · DOI: 10.5530/ijper.krupapharmacon.27 · 2026

Objectives: The present study aims to systematically develop a Self-Emulsifying Drug Delivery System (SMEDDS) of Rosuvastatin using a (QbD) framework. Materials and Methods: The formulation development was initiated by d…

Masali Aditya, Mayukh Sarkar, Soumya K M

pp. 112-122 · DOI: 10.5530/ijper.krupapharmacon.28 · 2026

Background: Alzheimer’s Disease (AD) is a common neurological condition characterised by progressive deficits in cognition, memory, and behavior. Its pathology involves cholinergic dysfunction, neuronal loss, and oxidati…

Kavya P Reddy, Prem Kumar Nanjundan, Shireesha K R, Gouranga Boruah, Prajal Chhetri

pp. 123-132 · DOI: 10.5530/ijper.krupapharmacon.29 · 2026

Background: Unhealthy dietary patterns, particularly high-fat high-fructose diets, are closely linked to metabolic conditions (resistance to insulin) that may lead to anxiety-related behaviors and neuro inflammation. A d…

Ramadevi Pemmereddy, Swathi Boddupally, Namratha Sunkara, Priyanka Budime, Kusume Sireesha, Prathiksha Thakre, Meghana Rameshwaram, Pallavi Nagesh, Haritha Pasupulati

pp. 133-140 · DOI: 10.5530/ijper.krupapharmacon.30 · 2026

Objectives: Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder predominantly affecting the elderly population and is characterized by memory loss, cognitive impairment, and behavioural disturbances. Des…

S Mega Varsha, Prarthana Upadhyaya, Swetha Saji, Anjaly Sivakumar, Roshan Manoharan

pp. 141-149 · DOI: 10.5530/ijper.krupapharmacon.31 · 2026

Background: Chronic Urticaria (CU) is a debilitating dermatological condition significantly impacting patient quality of life. Second-generation H1-antihistamines, such as bilastine and fexofenadine, are universally reco…

Baby Shalini S N, Jyothi Yachamaneni, Sahana H S

pp. 150-158 · DOI: 10.5530/ijper.krupapharmacon.32 · 2026

Background: Persea americana (Avocado) seeds contain flavonoids, phenolic compounds, rutin, and catechin derivatives possessing antioxidant and neuroprotective activities. Previous studies have reported free radical scav…

Punit Sultanpure, Paramita Das, Gururaj G M, Amit Agarwal, Pooja Turkani, Sharath J

pp. 159-167 · DOI: 10.5530/ijper.krupapharmacon.33 · 2026

Background and Objectives: The present study aimed to develop HPTLC fingerprint profiles and perform densiometric quantification of specific phytochemical markers in Cymbopogon Citratus (Lemongrass), Ocimum Sanctum (Tula…

Bhumika Chettri, Sekhar Sharma, Manisha Bihani, Raman Dang

pp. 168-177 · DOI: 10.5530/ijper.krupapharmacon.34 · 2026

Objectives: The main aim of this investigation was to conduct a detailed Pharmacognostical and phytochemical characterization of Elaeocarpus ganitrus leaf material sourced from the East Sikkim region of India. Materials …

Jasmin Sajini Rajayan, Akshaya Kumaravel, Mohamed Anas Abdul Rahim, Vinodhini Chandrasekar, Mubeen Mohamed Ibrahim Bahadur khan, Vijila Helen Mary George, Karthik Rajendran, Anjali Nayak

pp. 178-188 · DOI: 10.5530/ijper.krupapharmacon.35 · 2026

Background and Aim: Ixora finlaysoniana is a flowering plant belonging to the family Rubiaceae, commonly found in tropical regions and valued for its ornamental clustered inflorescences and aesthetically attractive flowe…

Satabdi Goswami, Apurwa Salunkhe, Bhabitha Peyyala, Shreesha S

pp. 189-198 · DOI: 10.5530/ijper.krupapharmacon.36 · 2026

Objectives: The antidiabetic and antioxidant activity of the hydroalcoholic extract of the Azadirachta indica (Neem), a member of the family Meliaceae is studied by the In vitro evaluation that is by phytochemical screen…

Haritha Pasupulati, Namratha Sunkara, Budime Priyanka, Kusume Muneesha, Ramadevi Pemmireddy, Swathi Boddupally, Rentala Glory Therissa, Korukollu Jnanendra Kumar, Kusume Sireesha, Usharani U

pp. 199-206 · DOI: 10.5530/ijper.krupapharmacon.37 · 2026

Objectives: The global rise in opportunistic and systemic fungal infections, coupled with increasing resistance to conventional azole antifungal agents, has created an urgent demand for novel antifungal chemotypes with i…

Ravindra Ashritha, Manandi Krishna Murthi Ranganath, Kedar Bharadwaj Nayak

pp. 207-219 · DOI: 10.5530/ijper.krupapharmacon.38 · 2026

Aim: Vertigo, nausea, motion sickness and vomiting due to gastrointestinal and vestibular diseases are controlled by the Combination of Cinnarizine (CIN) and Domperidone (DOM). A rapid, stable and accurate RP-UPLC method…