Anti-inflammatory and Antioxidant Activities of Methanolic extract of Buchanania Lanzan Kernel

Abstract:

The present study was an endeavor to evaluate anti-inflammatory and antioxidant activity of methanolic extract of Buchanania lanzan kernel (BLK-ME). The in vivo anti-inflammatory activity was evaluated in rats by using carrageenan-induced paw edema, as an acute model and formaldehyde induced arthritis as a chronic model, whereas in vitro antioxidant activity was performed by 1, 1-diphenyl-2-picryl-hydrazyl (DPPH) and reducing power method. Quantitative estimation of total polyphenolic content of the (BLK-ME) was estimated by Folin-Ciocalteu method. BLK-ME (200 mg/kg body wt) significantly decreased paw volume, after oral administration of BLK-ME in carrageenan and formaldehyde injection. BLK-ME also exhibit significant antioxidant activity. Total polyphenolic content was found to be 16.82 %± 23 mg of GAE/100. Presence of phytochemicals like triterpenoids, saponins and tannins in the BLK-ME might contribute to the observed anti-inflammatory and antioxidant activity.

Key words: Buchanania lanzan kernel, Antioxidant, Anti-inflammatory, Polyphenols, DPPH