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Published on:10th Feb 2015
Indian Journal of Pharmaceutical Education and Research, 2010; 44(4):358-362
Pharmaceutical Education | doi:Nill

Microwave Assisted Synthesis and Biological Evaluation of Pyrazole Derivatives of Benzimidazoles


Authors and affiliation (s):

R. Kalirajan*, Leela Rathore, S. Jubie, B.Gowramma, S. Gomathy, S. Sankar and K. Elango

Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Ooty - 643001, Tamilnadu

Abstract:

A series of pyrazole derivatives of benzimidazole were synthesized. Condensation of substituted o-phenylene diamine with lactic acid under microwave irradiation and further oxidation of the product with potassium dichromate gave intermediate 2-acetyl benzimidazole which was then reacted with aromatic aldehydes and finally the product was cyclized with hydrazine to form pyrazole derivatives of benzimidazoles. Compounds IVa,b,c,d,e have shown significant anti bacterial and compounds IV b,g have shown significant anti cancer activity when compared with standard drugs.

Key words: benzimidazole, pyrazole, anti cancer and antibacterial

 




 

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