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Published on:10th Feb 2015
Indian Journal of Pharmaceutical Education and Research, 2010; 44(4):369-374
Research Article | doi:Nill

Phytochemical investigation and evaluation of anthelmintic activity of extract from leaves of Eupatorium odoratum linn


Authors and affiliation (s):

Debidani Mishra1 *, Deb Kumar Sarkar1, Bhabani Shankar Nayak1, Prasant Kumar Rout1, P. Ellaiah1 and S. Ramakrishna2

1Department of Pharmacognosy, Faculty of Pharmacy, Jeypore College of Pharmacy, Rondapalli, Jeypore - 764002, Koraput, Orissa, India.

2Department of Pharmacognosy, Faculty of Pharmacy, College of Pharmaceutical Sciences, Mohuda, Berhampur – 760002, Odisha, India.

Abstract:

Eupatorium odoratum Linn is found in the tribal area of Koraput district and extensively used traditionally by the tribal people as anthelmintic, antimicrobial, antifungal and wound healing. The present study is an attempt to preliminary investigation of phytochemical constituent and to explore the anthelmintic activity of different extracts of leaves of plant Eupatorium odoratum using petroleum ether, ethanol and chloroform as solvents. The various doses of extracts were screened for phytochemical constituent and evaluated for their anthelmintic activities on adult Indian earthworms, Pheretima posthuma. Tests for alkaloid and tannins were positive in all extracts except tannin was absent in petroleum ether. Tests for saponin, protein, aminoacid and anthraquinone glycoside were negative in all extracts. All extracts were able to show anthelmintic activity at 2.5 mg/ml concentration. The activities are comparable with the standard drugs, piperazine citrate and albendazole. All the doses of petroleum ether, ethanol and chloroform extracts of Eupatorium odoratum showed better anthelmintic activity than the standard drug albendazole except petroleum ether extract at 2.5 mg/ml of concentration. The extracts of three solvents at concentration of 2.5 and 5.0 mg/ml showed lesser anthelmintic activity than the standard drug piperazine citrate. When the dose of the extract is increased, a gradual increase in anthelmintic activity was observed. The ethanolic extract showed better anthelmintic activity in comparison with petroleum ether and chloroform extracts. The data were verified as statistically significant by using one way ANOVA at 5 % level of significance (p < 0.05).

Key Words: Eupatorium odoratum; Asteraceae; Anthelmintic; Piperazine citrate; Albindazole.

 




 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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