Nephroprotective effect of Dichrostachys cinerea Bark Extract against Streptozotocin Induced Diabetic Nephropathy Via Alteration of Oxidative Stress and Inflammation

Indian Journal of Pharmaceutical Education and Research

  • Kavitha Kandasamy1Department of Biochemistry, Vivekanandha College of Arts and Sciences for Women, Tiruchengode, Namakkal, Tamil Nadu, INDIA.
  • Zain Alabden Ghanim Ahmed Ahmed2College of Pharmacy, Al-Kitab University, Kirkuk, IRAQ.
  • Zead Helmi Abudayeh3Basic Pharmaceutical Sciences Department, Faculty of Pharmacy, Isra University, Amman, JORDAN.
  • Samer Hasan Hussein-Al-Ali4Department of Chemistry, Faculty of Sciences, Isra University, Amman, JORDAN.
  • Shilpa Perumal Narasimhamoorthi5Centre for Applied Research, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, Tamil Nadu, INDIA.
  • Palanisamy Arulselvan6Department of Biochemistry, Karpagam Academy of Higher Education (Deemed to be University), Coimbatore, Tamil Nadu, INDIA.
  • Karunakaran Saravanan7Department of Chemical Engineering, KPR Institute of Engineering and Technology, Avinashi Road, Arasur, Coimbatore, Tamil Nadu, INDIA.
  • Subbarayan Sarathbabu8Muthayammal Centre for Advanced Research, Muthayammal College of Arts and Science, Rasipuram, Namakkal, Tamil Nadu, INDIA.

Volume 60 Issue 4 Pages 1720-1729

DOI: 10.5530/ijper.20264263

Abstract

Introduction: The primary trigger of End-Stage Renal Disease (ESRD) in several affluent nations, including the US, is diabetic nephropathy. Objectives: Diabetic nephropathy is a microvascular consequence that can occur in patients with Type 1 Diabetes (T1D) or Type 2 Diabetes (T2D). Because of its anti-inflammatory and antioxidant effects, Dichrostachys cinerea (L.) Wight and Arn. (DC) treats many inflammatory diseases, especially rheumatoid arthritis. Materials and Methods: The experimental rats were given an intraperitoneal dose of 60 mg/kg of STZ to cause diabetes. Following diabetic induction, fasting blood glucose samples were taken on the 0thand 30th day. Following the study, we evaluated the activity of pro-inflammatory indicators, renal biochemical markers, and levels of oxidative and antioxidant stress following DCBE treatment. Results: Glibenclamide is an anti-diabetic medication that was utilized in the study to compare treatment with DCBE. When DCBE was administered to STZ-induced diabetic rats, the levels of ROS, plasma AGEs, BUN, Serum Creatinine, uric acid, NAG, and U-mAIb were found to decrease. TNF-α, IL-1β, and IL-6 activities were all markedly downregulated. Following DCBE treatment, SOD, GSH, and GPx levels increased. Conclusion: According to the current investigation, DCBE treatment alleviated STZ-induced diabetes in a manner comparable to that of glibenclamide treatment. It might therefore be utilized as a possible treatment for diabetic nephropathy in the future.

Keywords

  • Dichrostachys Cinerea Bark Extract (DCBE)
  • Glibenclamide
  • Streptozotocin (STZ)
  • Diabetic Nephropathy (DN)
  • Oxidative stress
  • Pro-inflammatory biomarkers
  • Renal biochemical markers
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