Development and Characterization of Ranolazine-Loaded Solid Lipid Nanoparticles for Enhanced Angina Therapy

Indian Journal of Pharmaceutical Education and Research

  • Prasanna Shirgaonkar1Department of Pharmaceutical Quality Assurance, Tatyasaheb Kore College of Pharmacy, Warananagar, Warana University, Warananagar, Kolhapur, Maharashtra, INDIA.
  • Rutuja Chougale2Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Near Chitranagari, (Affiliated to Shivaji University), Kolhapur, Maharashtra, INDIA.
  • Kiran Patil1Department of Pharmaceutical Quality Assurance, Tatyasaheb Kore College of Pharmacy, Warananagar, Warana University, Warananagar, Kolhapur, Maharashtra, INDIA.
  • Vibhuti Thakur1Department of Pharmaceutical Quality Assurance, Tatyasaheb Kore College of Pharmacy, Warananagar, Warana University, Warananagar, Kolhapur, Maharashtra, INDIA.
  • Firoj Tamboli3Department of Pharmacognosy, Bharati Vidyapeeth College of Pharmacy, Near Chitranagari (Affiliated to Shivaji University), Kolhapur, Maharashtra, INDIA.
  • Somnath Bhinge4Department of Pharmaceutical Quality Assurance, Krishna Institute of Pharmacy, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, Maharashtra, INDIA.
  • Shailendra Gurav5Department of Pharmacognosy and Phytochemistry, Goa College of Pharmacy, Goa University, Goa, INDIA.

Volume 60 Issue 4 Pages 1409-1415

DOI: 10.5530/ijper.20261392

Abstract

Background: The study focuses on the development and characterization of Ranolazine-loaded Solid Lipid Nanoparticles (RNZ-SLNs) to enhance therapeutic efficacy and safety in angina therapy. Materials and Methods: RNZ-SLNs were synthesized using a heated homogenization process followed by ultrasonication. The formulation was characterized for particle size, zeta potential, % entrapement efficiency, and in vitro drug release profile. Biocompatibility was evaluated using in vitro hemolysis studies. Results and Discussion: The results of the study demonstrated that the formulated Ranolazine-loaded Solid Lipid Nanoparticles (RNZ-SLNs) exhibited favorable physicochemical properties essential for effective drug delivery. The particle size of the RNZ-SLNs was found to be 254.1±2.4 nm, indicating their suitability for nanoparticle-based drug delivery systems. The zeta potential of -15.3±1.8 mV reflected sufficient stability of the formulation, while the % entrapement efficiency of 75.15±3.1% confirmed the effective incorporation of Ranolazine within the lipid matrix. The in vitro drug release profile revealed a significantly enhanced release rate for RNZ-SLNs, achieving 61.807±2.51% over 24 hr, compared to the plain Ranolazine dispersion, which released only 36.807±2.08% within the same period. Furthermore, in vitro hemolysis studies indicated a marked improvement in biocompatibility for RNZ-SLNs, with a hemolytic effect of 9.17%, compared to 19.23% observed for plain Ranolazine. These findings collectively highlight the potential of RNZ-SLNs to improve the therapeutic efficacy and safety profile of Ranolazine for angina therapy. Conclusion: RNZ-SLNs demonstrated superior therapeutic potential, including improved drug release and biocompatibility, suggesting their promise as an effective and safe delivery system for Ranolazine in angina therapy.

Keywords

  • Angina
  • Pluronic F108
  • Ranolazine
  • Solid lipid nanoparticles
  • Stearic acid
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