Formulation and Evaluation of Beclomethasone Dipropionate Loaded Niosomal Gel for Topical Use

Abstract

Background: The present study focuses on the formulation and evaluation of a niosomal gel containing beclomethasone dipropionate for topical delivery, with the objective of enhancing skin permeability and achieving sustained drug release. Niosomes, which are spherical vesicles composed of non-ionic surfactants, offer several advantages over conventional drug delivery systems, including higher drug loading capacity, controlled release, and reduced systemic side effects. Materials and Methods: In this study, niosomes were prepared using the thin-film hydration technique by optimizing the ratios of Span 60 and cholesterol. The prepared niosomal dispersions were subsequently incorporated into a Carbopol-based gel and subjected to comprehensive evaluation. Evaluation Parameters: Various parameters, including vesicle size, entrapment efficiency, pH, spreadability, drug content, and in vitro drug release, were assessed. Results/Conclusion: The results demonstrated that the optimized niosomal gel possessed favorable physicochemical properties, exhibited sustained drug release, and showed significant potential as an effective topical drug delivery system.