The Interplay between Traumatic Brain Injury, Cocaine Abuse, and Genetic Mutations in the Development of Parkinsons Disease: A Review

Indian Journal of Pharmaceutical Education and Research

  • Mohamad Qutboddin1Depatment of Pharmacology, Faculty of Pharmacy, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B. G. Nagara, Karnataka, INDIA.
  • Syed Sagheer Ahmed2Department of Pharmacology, Akshaya Institute of Pharmacy, Tumkur, affiliated to Rajiv Gandhi University of Health Science, Bengaluru, Karnataka, INDIA.
  • Nahid Abbas3Department of Chemistry, Akshaya Institute of Pharmacy, Tumkur, affiliated to Rajiv Gandhi University of Health Science, Bengaluru, Karnataka, INDIA.
  • Mohammad Ali
  • Bharathi Doddla Raghunathanaidu

Volume 60 Issue 3 Pages 918-924

DOI: 10.5530/ijper.20262583

Abstract

Parkinson's Disease (PD) is a neurodegenerative disorder characterized by the depletion of dopamine neurotransmitters and receptors. Although the etiology of PD is multifactorial, emerging evidence suggests that Traumatic Brain Injury (TBI), cocaine abuse, and genetic mutations may contribute to the development and progression of PD. This review summarizes the current understanding of the interplay between TBI, cocaine abuse, and genetic mutations in DA homeostasis in PD. Here, we discuss the molecular mechanisms underlying DA depletion and receptor dysfunction in PD, and how TBI, cocaine abuse, and genetic mutations may exacerbate these processes. Ultimately, a complex relationship between TBI, cocaine abuse, genetic mutations in dopamine, and PD has been identified.

Keywords

  • Cocaine abuse
  • Dopamine
  • Genetic mutation
  • Parkinson's disease
  • Traumatic brain
  • injury
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