Therapeutic Potential of Nanosilver Encapsulated Polysaccharide in Wound Healing

Abstract

Chronic wounds create a major threat for an individual, which, if neglected, can cause severe infection in the form of sepsis. Therefore, early clinical diagnosis is very crucial to prevent further complications. Since conventional treatments are often inadequate and may lead to scar, innovative wound healing strategies are in greater demand. Recently, silver nanoparticles, due to their wide antimicrobial activity, greater surface area, and functionalization property, have garnered attention in wound healing. Apart from that, natural polysaccharides, due to their biodegradable, biocompatible, flexible properties and inherent antimicrobial and antioxidant properties, are gaining popularity in addressing the needs of wound healing. Despite their widespread use, silver nanoparticles and natural polysaccharides face certain stability issues and other formulation-related challenges. This paper outlines the mechanism and applications of silver nanoparticles and polysaccharides in wound healing and their limitations. The review thoroughly inspects the recent research to explore the strategies adapted to overcome the limitations of silver nanoparticles and advocates the use of the additive effect of polysaccharides and silver nanoparticles in formulation. Silver Nanoparticles are being conjugated with natural polysaccharides termed as Nanocomposites, which lower their cytotoxic potential and show additive effects as the polysaccharide itself possesses wound healing capacity. The paper focuses on Nano Silver-Polysaccharide conjugation, which provides better results in wound recovery and antimicrobial potency. Therefore, the present review focuses on the conjugation of silver nanoparticles and polysaccharides for an advanced and effective strategy for wound healing and emphasizes future research work in this arena.