Combined Raft Formation-Interpenetrating Complex Approach to Reconstitutable Sustained-Release Suspension Development

Indian Journal of Pharmaceutical Education and Research

  • Pallavi Asaram Chandewar1Department of Pharmaceutics, Institute of Pharmaceutical Education and Research, Borgaon (Meghe), Wardha, Maharashtra, INDIA.
  • Dilesh Jagdish Singhavi1Department of Pharmaceutics, Institute of Pharmaceutical Education and Research, Borgaon (Meghe), Wardha, Maharashtra, INDIA.
  • Prachi Pradiprao Gedam2Department of Pharmacognosy, Institute of Pharmaceutical Education and Research, Borgaon (Meghe), Wardha, Maharashtra, INDIA.
  • Nilesh Ashok Karande3Department of Pharmaceutical Chemistry, Institute of Pharmaceutical Education and Research, Borgaon (Meghe), Wardha, Maharashtra, INDIA.
  • Rajendra Onkarappa Ganjiwale2Department of Pharmacognosy, Institute of Pharmaceutical Education and Research, Borgaon (Meghe), Wardha, Maharashtra, INDIA.

Volume 60 Issue 2s Pages s617-s626

DOI: 10.5530/ijper.20261811

Abstract

Background: The foundation of this work is the use of raft formation and Interpenetrating Polymeric Network (IPN) complexation techniques to create a reconstitutable sustained-release suspension of Diltiazem Hydrochloride (DZH) for elderly patients. Materials and Methods: Xanthan gum and chitosan were used in combination to prepare IPN complexes of DZH. A central composite design was used to optimize the raft-forming in situ gelling system. The concentrations of HPMC K4M and sodium alginate were the independent variables. Results: In vitro dissolution, X-ray powder diffraction, and differential scanning calorimetric studies were conducted to examine the IPN complexes. The optimized batch (ratio of sodium alginate to HPMC K4M, 1500:100) exhibited gelation properties for an extended time period, as well as the desirable floating duration (>12 hr). A desirable drug release of 97.39±0.97% in up to 12 hr was achieved. The release kinetics of the DZH obeyed the Higuchi order of release following the Fickian diffusion mechanism with an n value of 0.366. Conclusion: The in vitro study suggested that a reconstitutable sustained-release suspension was successfully prepared using the raft forming formulation approach and the IPN complex of DZH. The optimized formulation exhibited sustained release of the water-soluble drug over 12 hr due to the combined effect of the RFGS and the IPN complex.

Keywords

  • Sustained Release
  • IPN Complex
  • In situ gel
  • Reconstituted Suspension
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