Formulation, Optimization and Evaluation of Barbaloin Loaded Phytosomal Gel for the Treatment of Psoriasis

Abstract

Background: Phytosomes are one such unique approach gaining popularity due to their capabilities in controlled release and targeted delivery. These advanced herbal formulations significantly enhance the bioavailability of phytochemicals, improving the therapeutic efficacy of Barbaloin by boosting solubility and absorption for the treatment of Psorisis. In this study, phytosomes were prepared using the thin film hydration method with soya lecithin and cholesterol to optimize encapsulation efficiency and particle size. Materials and Methods: Barbaloin, Soya lecithin, Cholesterol, Dichloromethane, Methanol, n- Hexane are all of these ingredients are were used for preparing barbaloin phytosome formulation. Carbopol 934, Polyethylene glycol 400, triethanolamine, methyl paraben and propyl paraben are used for preparation barbaloin loaded phytosomal gel. Prepared phytosomes were characterized for FTIR (Fourier transform infrared spectroscopy). It also underwent analysis for Particle size, Zeta potential, entrapment efficiency. Conclusion: Barbaloin phytosome was formulated using the thin film hydration technique and identified as an effective carrier for topical drug delivery. The system’s properties were notably affected by the drug-to-polymer ratio. In summary, phytosome-based drug delivery can enhance the therapeutic efficacy of phytochemicals by increasing absorption and bioavailability, while also modifying their physicochemical and release properties. Therefore, barbaloin phytosomal gel is a promising alternative for drug delivery.