Wogonoside Mitigates Inflammation and Cell Proliferation via Modulation of NF-κB Signalling Pathway in DMBA-Induced Mammary-Preclinical Model

Indian Journal of Pharmaceutical Education and Research

  • Chenyang He1The Comprehensive Breast Care Center, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, CHINA.
  • Yu Zhang1The Comprehensive Breast Care Center, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, CHINA.
  • Yan Diao1The Comprehensive Breast Care Center, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, CHINA.
  • Xingcong Ma1The Comprehensive Breast Care Center, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, CHINA.
  • Guochao Mao1The Comprehensive Breast Care Center, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, CHINA.
  • Xinyu Wei1The Comprehensive Breast Care Center, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, CHINA.
  • Yang Zhao1The Comprehensive Breast Care Center, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, CHINA.

Volume 59 Issue 4 Pages 1466-1473

DOI: 10.5530/ijper.20256082

Abstract

Objectives: To hypothesis the effect of wogonoside against DMBA-induced Breast Cancer (BC) via TNF-α induced NF-κB signaling pathway a molecular appraoch. Materials and Methods: A 25 mg/kg Body Weight (BW), DMBA mixed dosage was used to produce BC with 1 mL olive oil by subcutaneous injection. We observed reduced body weight, elevated hepatic marker (AST, ALP, ACP and ALT), phase I (Cyt-b5 and Cyt-p450) and lipid peroxidative (TBARS and LOOH) markers and reduced antioxidant and xenobiotic enzymes in DMBA induced cancer-bearing rats. Moreover, the molecular study revealed that up-regulation of, inflammatory (NF-κB p65, TNF-α, IL-6 and IL-1β) markers in DMBA treated cancer-bearing animals. Results: Oral supplementation of wogonoside substantially reverted back to normal levels of these DMBA-induced rats have biochemical and molecular indicators. Conclusion: Overall, these findings supported wogonoside anti-inflammatory and anti-cell proliferation activity against DMBA-induced breast cancer through modification of the NF-κB signaling pathway.

Keywords

  • Wogonoside
  • DMBA
  • Inflammation
  • Cell proliferation
  • NF-κB signaling
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