Effect of Ethanol Extract of Rosella Flower (Hibiscus sab- dariffa L.) on the Expression of Fibroblast Growth Factor-2 (FGF-2) and Matrix Metalloproteinase-1 (MMP-1) in the Healing Process of Incision Wounds in White Wistar Rats

Indian Journal of Pharmaceutical Education and Research

  • Ade Dwi Pratiwi1Medical Faculty, Masters Program in Biomedical Sciences, Universitas Methodist Indonesia, INDONESIA, INDONESIA.
  • Jekson Martiar Siahaan2Department of Physiology, Faculty of Medicine, Universitas Methodist Indonesia, Medan, INDONESIA.
  • Endy Juli Anto4Department of Parasitology and Immunology, Faculty of Medicine, Universitas Methodist Indonesia, Medan, INDONESIA.

Volume 59 Issue 3s Pages s921-s929

DOI: 10.5530/ijper.20250752

Abstract

Background: This study investigated the effect of rosella flower petal (Hibiscus sabdariffa L.) ethanol extract gel on incision wound healing in a rat model of diabetes mellitus. Wounds are skin disorders that can be caused by internal or external factors. The wound healing process involves various growth factors, including Fibroblast Growth Factor-2 (FGF-2) and Matrix Metalloproteinase-1 (MMP-1). Materials and Methods: This study used a post-test-only controlled group design with male Wistar rats as the research subjects. This study aimed to evaluate the effect of rosella flower petal ethanol extract gel on FGF-2 and MMP-1 levels, as well as collagen and fibroblast cell formation in the wound healing process. Results: Phytochemical screening results revealed the presence of flavonoids, alkaloids, saponins, phenols, and tannins in rosella extract. The results showed a significant difference (p<0.05) in FGF-2 levels between all research groups and significant difference (p<0.05) in MMP-1 levels. Conclusion: The group that received ethanol extract gel of rosella flower petals with a concentration of 12% showed a better increase in the formation of FGF-2, MMP-1, collagen, and fibroblast cells compared to the other groups

Keywords

  • Ethanol Extract Rosella Flower Petals
  • Incision Wounds
  • White rat
  • Wistar strain
IJOPP

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