A Review on Preparation Methods of Drug Loading Solid Lipid Nanoparticles with the Application in various Cancer Treatment

Abstract

The pharmaceutical and cosmetics industries, as well as the domains of research and clinical medicine, have all benefited from the advent of Solid Lipid Nanoparticles (SLN) as a promising new drug delivery technique. These SLN are receiving more and more interest as colloidal drug carriers for integrating hydrophilic or lipophilic medicines recently. Technology is the newest development in cancer therapy and numerous compounds are currently being studied for use in medication delivery. It aids the pharmacist in creating a product with the greatest therapeutic benefit and the fewest possible negative effects. Lack of selectivity for tumor tissue is a major problem with anticancer drugs, resulting in significant side effects and low cure rates. Cancer is a group of diseases characterized by the unchecked growth and division of aberrant cells. Significant advantages of SLNs include low toxicity, high drug bioavailability, flexible drug integration and the possibility of industrial-scale production. The molecular structure of SLN preparations is crucial to their quality and this structure is in turn determined by the composition and the method of production. Furthermore, SLNs allow for the circumvention of a number of physiological barriers that obstruct the transport of drugs to tumours and are also capable of evading the multidrug resistance mechanisms that are inherent to cancer cells. This review article discusses the various SLN preparation techniques, various aspects to enhance drug loading in SLNs, as well as potential applications in cancer targeted medication therapy followed by their stability aspects.