Cardio-Protective Effect of Malvidin against Doxorubicin-Stimulated Cardiotoxicity in Experimental Rat Models

Indian Journal of Pharmaceutical Education and Research

  • Xiaolong Mi1Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, CHINA.
  • Lili Zhang Yunxia Ren1Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, CHINA.
  • Tong Li1Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, CHINA.
  • Jinfang Cheng1Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, CHINA.

Volume 59 Issue 3 Pages 1016-1023

DOI: 10.5530/ijper.20250957

Abstract

Background: Malvidin (MAL) is an anthocyanidin having therapeutic characteristics that provide several therapeutic advantages. Doxorubicin (DOX) is a valuable anti-tumor drug with a wider anticancer range; nevertheless, DOX's cardiotoxic side effects via oxidative stress and apoptosis restrict its clinical use. There are various old and modern solutions that can aid with this predicament. Even decades after the drug's side effects were revealed, no successful strategy for managing this clinical disease has been found. The goal of the present investigation is to study the cardioprotective ability of the natural compound MAL against DOX-stimulated cardiotoxicity in rat models. Materials and Methods: Upon induction of cardiotoxicity and administration of MAL, assessment of parameters including heart and body weight, antioxidant levels, serum lipid profile, cardiac biomarker levels and inflammatory marker levels were carried out. Results: It was discovered that treatment with MAL remarkably protected the mice from DOX-triggered cardiotoxicity, as evidenced by increased heart and body weight, antioxidant enzyme levels, reduced levels of cardiac biomarker levels and inflammatory parameters and improved heart morphology. Conclusion: Thus, MAL demonstrated to be a valuable substance for protection of cardiac tissues against DOX-stimulated cardiotoxicity.

Keywords

  • Anti-inflammatory
  • Cardiotoxicity
  • Doxorubicin
  • Malvidin
  • Oxidative stress
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