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IJPER · Lens · In vitro Evaluation of Curcumin and Quercetin in Combination on Oxidative Stress

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Article · Volume 59, Issue 1s (Supplement) · pp. s214-s220

In vitro Evaluation of Curcumin and Quercetin in Combination on Oxidative Stress

Archita Katrolia1,2, Vedpal3, Vikesh Kumar Shukla4, Rohit Singh5, Sheenu Chandra3, Rajeshkumar Raman6

  1. 1Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, INDIA
  2. 2Department of Pharmaceutics, College of Pharmacy, JSS Academy of Technical Education, Noida, Uttar Pradesh, INDIA
  3. 3Department of Pharmacognosy, College of Pharmacy, JSS Academy of Technical Education, Noida, Uttar Pradesh, INDIA
  4. 4Centre for Drug Regulatory Affairs and Pharmacy Practice, Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, INDIA
  5. 5Department of Pharmaceutical Chemistry, College of Pharmacy, JSS Academy of Technical Education, Noida, Uttar Pradesh, INDIA
  6. 6Department of Pharmaceutical Biotechnology, JSS College of Pharmacy, Ooty, JSS Academy of Higher Education and Research, Myore, INDIA

Abstract

Background: Flavonoids are the natural product belongs to an important class of plant secondary metabolites. They are polyphenolic compounds and known for decades as a potent natural antioxidant. Curcumin (flavonoid polyphenol) and quercetin (flavonol) both are popular natural antioxidants and contributes a major role as an individual in the treatment of oxidative stress. This research study is more focused in their combination effect against oxidative stress.Materials and Methods: In this present research, we focused on hydro-alcoholic maceration of Curcuma longa rhizomes and Morinda citrifolia fruits to extract the curcumin and quercetin respectively. Also, their role in oxidative stress was studied using in vitro techniques.Results: The percentage (%) yield of hydro-alcoholic extract attained from Curcuma longa rhizomes and Morinda citrifolia fruits were found to be 23.06% and 21.08% respectively.Conclusion: Additionally, through DPPH (2,2-diphenyl-l-picrylhydrazyl) and Lipid peroxidation (LPO) assay, it was observed that curcumin and quercetin in combination gives the highest antioxidant activity when compared with their individual response at same concentration.

Keywords: Authentication; Hydro-alcoholic maceration; Curcumin; Quercetin; Flavonoids; Oxidative stress

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