An Insight into the Synthetic Strategies and Pharmacological Effects of Cinnoline Derivatives

Indian Journal of Pharmaceutical Education and Research

  • Shagun Saxena1Department of Pharmaceutical Chemistry, Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida, Uttar Pradesh, INDIA.
  • Rakhi Mishra1Department of Pharmaceutical Chemistry, Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida, Uttar Pradesh, INDIA.
  • Avijit Mazumder1Department of Pharmaceutical Chemistry, Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida, Uttar Pradesh, INDIA.
  • Rupa Mazumder1Department of Pharmaceutical Chemistry, Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida, Uttar Pradesh, INDIA.
  • Mohd Shuaib2Department of Pharmacognosy and Phytochemistry, Kalka Institute for Research and Advanced Studies, Kalka Group of Institutions, Meerut, Uttar Pradesh, INDIA.

Volume 59 Issue 1 Pages 13-29

DOI: 10.5530/ijper.20253735

Abstract

Background: The cinnoline ring is a new aromatic heterocyclic connected with two nitrogen atoms in a 6 membered ring and compounds containing this ring have been shown to have a wide variety of pharmacologicaleffects. Objectives: This review studyextensively explains the synthetic strategy by which researchers have produced cinnoline derivatives reported to have numerous pharmacological effects, including antitubercular, antibacterial, anticancer, antimolluscidal, etc. Materials and Methods: The cinnoline moiety is a highly powerful lead that may give a range of pharmacological effects and this study provides brief information on the various synthesis techniques and pharmacological activity of reported cinnoline analogs that support this claim. Results: This succinct review summarizes the several known cinnoline analogs, outlining their respective synthesis strategies and pharmacological activity and conclusively showing that the cinnoline moiety is a potent lead capable of producing a wide range of therapeutic actions. Conclusion: This article’s literature review will serve as a springboard for further research into the synthesis of cinnoline derivatives, which in turn will aid in the creation of cinnoline-based compounds with improved pharmacokinetic and pharmacodynamic characteristics.

Keywords

  • Cinnoline
  • Aromatic
  • Synthesis
  • Pharmacokinetic
  • Heterocyclic
  • Pharmacological effects
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