Research Progress of Baicalin Interactions with the Animal Gut Microbiome
Indian Journal of Pharmaceutical Education and Research
Peirong Chen1Laboratory of Veterinary Pharmacology and Toxicology, College of Animal Science and Veterinary Medicine, Xinyang Agriculture and Forestry University, Xinyang, PEOPLE’S REPUBLIC OF CHINA.
Bingjie Ma1Laboratory of Veterinary Pharmacology and Toxicology, College of Animal Science and Veterinary Medicine, Xinyang Agriculture and Forestry University, Xinyang, PEOPLE’S REPUBLIC OF CHINA.
Jinni Liu1Laboratory of Veterinary Pharmacology and Toxicology, College of Animal Science and Veterinary Medicine, Xinyang Agriculture and Forestry University, Xinyang, PEOPLE’S REPUBLIC OF CHINA.
Min Zhang1Laboratory of Veterinary Pharmacology and Toxicology, College of Animal Science and Veterinary Medicine, Xinyang Agriculture and Forestry University, Xinyang, PEOPLE’S REPUBLIC OF CHINA.
Jinzhe Li1Laboratory of Veterinary Pharmacology and Toxicology, College of Animal Science and Veterinary Medicine, Xinyang Agriculture and Forestry University, Xinyang, PEOPLE’S REPUBLIC OF CHINA.
Haigang Wu1Laboratory of Veterinary Pharmacology and Toxicology, College of Animal Science and Veterinary Medicine, Xinyang Agriculture and Forestry University, Xinyang, PEOPLE’S REPUBLIC OF CHINA., 2Laboratory of Veterinary Pharmacology and Toxicology, College of Animal Medicine, Huazhong Agricultural University, Wuhan, PEOPLE’S REPUBLIC OF CHINA.
Homeostasis of the animal gut microbiome is essential for maintaining intestinal health and normal growth and development. Baicalin is an O-glucuronidated flavonoid that possesses strong anti-bacterial, anti-inflammatory and antioxidant activities. Its addition to animal feed can alter gut microbial community composition, diversity and production of bacterial metabolites while decreasing production of pro-inflammatory cytokines and other factors that compromise the integrity of the epithelial cell barrier. This review thus summarizes the research progress of baicalin and regulation of the gut microbiota to provide guidance for the potential application of this compound for animal production as an antibiotic alternative.
