A Novel Approach on Micro Sponges Drug Delivery System: Method of Preparations, Application, and its Future Prospective

Indian Journal of Pharmaceutical Education and Research

  • Suraj Mandal1Department of Pharmacy, IIMT College of Medical Sciences, IIMT University, O-Pocket, Ganga Nagar, Meerut, Uttar Pradesh, INDIA.
  • Km. Bhumika1Department of Pharmacy, IIMT College of Medical Sciences, IIMT University, O-Pocket, Ganga Nagar, Meerut, Uttar Pradesh, INDIA.
  • Mukesh Kumar1Department of Pharmacy, IIMT College of Medical Sciences, IIMT University, O-Pocket, Ganga Nagar, Meerut, Uttar Pradesh, INDIA.
  • Jiyaul Hak1Department of Pharmacy, IIMT College of Medical Sciences, IIMT University, O-Pocket, Ganga Nagar, Meerut, Uttar Pradesh, INDIA.
  • Prabhakar Vishvakarma1Department of Pharmacy, IIMT College of Medical Sciences, IIMT University, O-Pocket, Ganga Nagar, Meerut, Uttar Pradesh, INDIA.
  • Umesh Kumar Sharma1Department of Pharmacy, IIMT College of Medical Sciences, IIMT University, O-Pocket, Ganga Nagar, Meerut, Uttar Pradesh, INDIA.

Volume 58 Issue 1 Pages 45-63

DOI: 10.5530/ijper.58.1.5

Abstract

Microsponges are porous microspheres ranging in size from 5 to 300 micrometers used in a polymeric delivery system. They have been studied for biomedical applications, including targeted medicine delivery, transdermal drug delivery, anticancer drug delivery, and bone substitutes. This research aims to conduct a detailed examination of existing trends and future prospects for a microsponge-based medicine delivery system. The current study investigates the Microsponge Delivery System's design, operation, and possible therapeutic uses (MDS). The therapeutic potential of microsponge-based formulations, as well as patent data, were thoroughly investigated. The authors discuss several efficient methods for producing microsponges, including liquid-liquid suspension polymerization, quasi-emulsion solvent diffusion, water-in-oil-in-water (w/o/w) emulsion solvent diffusion, oil-in-oil emulsion solvent diffusion, the lyophilization method, the porogen addition method, the vibrating orifice aerosol generator method, the electrohydrodynamic atomization method, and the ultrasound-assisted microsponge. Microsponge may reduce undesired side effects and increase drug stability by boosting drug release. Hydrophilic and hydrophobic drugs can be loaded into a microsponge and transported to a specific target. When compared to traditional distribution methods, microsponge delivery technology offers numerous advantages. Microsponges, which are spherical, sponge-like nanoparticles with porous surfaces, can help increase drug stability. They efficiently alter drug release while also reducing adverse effects

Keywords

  • Microsponge
  • Microsponge delivery system
  • Novel drug delivery system
  • Quasi
  • emulsion solvent diffusion
  • Vibrating orifice aerosol generator
  • Electrohydrodynamic atomization
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