Multicomponent Synthesis, Characterization of Novel Pyrimidine Derivatives with Anti-cancer Potential

Indian Journal of Pharmaceutical Education and Research

  • Swetha Devidi1Department of Pharmacy, Faculty of Engineering and Technology, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, INDIA.
  • M Swamivel Manickam1Department of Pharmacy, Faculty of Engineering and Technology, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, INDIA.
  • R Suresh1Department of Pharmacy, Faculty of Engineering and Technology, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, INDIA.

Volume 57 Issue 3s Pages s742-s748

DOI: 10.5530/ijper.57.3s.84

Abstract

Background: Design and development of target specific anti-cancer agents is a central research goal. Materials and Methods: Substituted pyrimidines were synthesized from substituted enamine, triethoxy methane and ammonium acetate. Characterization was done using IR, 1H-NMR, and mass spectra. Cytotoxicity was tested using MTT Assay on A 549, B16F10, SiHA, and MCF-7 cells. Results: Synthesized derivatives displayed noticeable cytotoxicity against tested cancer cell lines. Conclusion: Evaluated cell lines were susceptible to the novel pyrimidine derivatives, which may be transformed into potent anti-cancer leads.

Keywords

  • Multicomponent synthesis
  • Pyrimidines
  • Anti-cancer
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