Article · Volume 57, Issue 3s (Supplement) · pp. s710-s717
In vitro and in vivo Antidiabetic Activity of Ag Nanoparticles Mediated from Gymnemic Acid I and II
Navanita Sivaramakumar1, Kalakotla Shanker1
- 1Department of Pharmacognosy, JSS College of Pharmacy, Ooty, Nilgiris, Tamil Nadu, INDIA.
Abstract
Background: Gymnema sylvestre is traditionally used to treat diabetes in Asia.Materials and methods: GA-I and GA-II were docked to PTP 1B. Nanoparticles were produced using centrifugation green synthesis.Results: Blood glucose levels significantly decreased (p less than 0.001) at a dose of 200 mg/kg of GA-I mediated AgNPs.Conclusion: GA-I mediated AgNPs can be exploited as prospective nanomedicine for type-2 diabetes.
Keywords: Gymnemic Acid-I; Molecular docking; PTP 1B
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