In vitro and in vivo Antidiabetic Activity of Ag Nanoparticles Mediated from Gymnemic Acid I and II

Indian Journal of Pharmaceutical Education and Research

  • Navanita Sivaramakumar1Department of Pharmacognosy, JSS College of Pharmacy, Ooty, Nilgiris, Tamil Nadu, INDIA.
  • Kalakotla Shanker1Department of Pharmacognosy, JSS College of Pharmacy, Ooty, Nilgiris, Tamil Nadu, INDIA.

Volume 57 Issue 3s Pages s710-s717

DOI: 10.5530/ijper.57.3s.80

Abstract

Background: Gymnema sylvestre is traditionally used to treat diabetes in Asia. Materials and methods: GA-I and GA-II were docked to PTP 1B. Nanoparticles were produced using centrifugation green synthesis. Results: Blood glucose levels significantly decreased (p less than 0.001) at a dose of 200 mg/kg of GA-I mediated AgNPs. Conclusion: GA-I mediated AgNPs can be exploited as prospective nanomedicine for type-2 diabetes.

Keywords

  • Gymnemic Acid-I
  • Molecular docking
  • PTP 1B
IJOPP

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