Syringodium isoetifolium Fosters an Antioxidant Defense System, Modulates Glycolytic Enzymes and Protects Membrane Integrity in DEN-induced Hepatocellular Carcinoma in Albino Wistar Rats

Indian Journal of Pharmaceutical Education and Research

  • Dhanaraju Kavitha1Department of Biochemistry, Vels Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai, Tamil Nadu, INDIA., Department of Pharmaceutical Chemistry, GIET School of Pharmacy, Rajahmundry, Andhra Pradesh, INDIA.
  • Ramakrishnan Padmini1Department of Biochemistry, Vels Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai, Tamil Nadu, INDIA.
  • Magharla Dasaratha Dhanaraju2Department of Pharmaceutical Chemistry, GIET School of Pharmacy, Rajahmundry, Andhra Pradesh, INDIA.
  • Chandravadivelu Gopi2Department of Pharmaceutical Chemistry, GIET School of Pharmacy, Rajahmundry, Andhra Pradesh, INDIA.
  • Deepan Thiyagarajan2Department of Pharmaceutical Chemistry, GIET School of Pharmacy, Rajahmundry, Andhra Pradesh, INDIA.
  • Alekkhya Veeramaneni2Department of Pharmaceutical Chemistry, GIET School of Pharmacy, Rajahmundry, Andhra Pradesh, INDIA.

Volume 57 Issue 3s Pages s690-s700

DOI: 10.5530/ijper.57.3s.78

Abstract

Background: Syringodium isoetifolium seagrass has bioactive constituents with potential pharmacological uses, but their use is limited. Materials and methods: Wistar albino rats were split into five groups. Except for group I, remaining all received DEN and Phenobarbitone. Extracts were administered to group III and IV orally with the dose of 250 and 500 mg/kg. 5 fluorouracil 20mg/kg was the standard. Results: The findings show that Syringodium isoetifolium significantly reduces liver tumor volume, burden and numbers in experimental rats (p less than 0.05). Besides, the extracts treated groups restored the pathological parameters close to normal values. Conclusion: The study concludes that Syringodium isoetifolium inhibits cancer growth by altering the antioxidant defense system, glycolysis and protecting membrane architecture.

Keywords

  • Syringodium isoetifolium
  • Wistar albino rats
  • Hepatocellular carcinoma
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