Binding Study of Monohydroxy Cucurbit[7]uril with Rhodamine B

Indian Journal of Pharmaceutical Education and Research

  • Karuppasamy Karpagalakshmi1International Research Center and Department of Chemistry, Kalasalingam Academy of Research and Education (Kalasalingam University), Virudhunagar, Tamil Nadu, INDIA.
  • Ramesh Prakash
  • Usha Govindaraj
  • Radhakrishnan Sathish Kannan
  • Lakshminarayanan Piramuthu
  • Narayanan Selvapalam

Volume 57 Issue 3 Pages 822-826

DOI: 10.5530/ijper.57.3.100

Abstract

Background: Cucurbit[7]uril (CB[7]) is the most important host among the reported cucurbit[n]urils family members, because it exhibited unique molecular recognition with exceptional applications. The binding affinity of functionalized CBs, especially mono hydroxylated CB[7] is important, because it will help to understand the difference in binding profile of functionalized CB[7] in comparison to that of the parent CB[7]. Materials and Methods: We have utilized Rhodamine B (RhB) to get encapsulated in monohydroxy CB[7] (CB[7]-OH) and measured the binding affinity of RhB in water. Results: The binding properties showed that the CB[7]-OH and RhB formed a 1:1 host-guest complex and the binding constant was found to be 3.75 × 104 M-1, which is slightly lower than the binding affinity of the parent molecule CB[7], which indicates that the binding behavior of CB[7]-OH not deviated much from the parent CB[7] molecule. Electrostatic Potential studies of these two molecules also supported these results. Conclusion: The binding studies of monohydroxy CB[7] (CB[7]-OH) successfully studied with RhB in water.

Keywords

  • Cucurbit[7]uril
  • Encapsulation
  • Host-guest chemistry
  • Rhodamine B
  • Binding constant
  • Monohydroxy-Cucurbit[7]uril
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