Chemical Composition, Antioxidant and Anti-tumor Activities of the Aerial Parts of Cometes abyssinica R.Br. ex Wall

Indian Journal of Pharmaceutical Education and Research

  • Ahmed AM Abdelgawad1Department of Medicinal and Aromatic Plants, Desert Research Center, Cairo, EGYPT., 2Department of Chemistry, Faculty of Science, Jazan University, Jizan, SAUDI ARABIA.

Volume 57 Issue 2 Pages 459-465

DOI: 10.5530/ijper.57.2.56

Abstract

An in vitro bioassay-guide revealed that the methanolic extract of the aerial parts of Cometes abyssinica had considerable inhibitory activity against colon (HCT-116) and hepatocellular (HepG2) carcinoma cell lines with IC50 24.4 and 29.9 μg/mL, respectively, compared to the drug reference Cisplatin. On the other hand, all studied extracts exhibited weak antioxidant activities using the DPPH scavenging assay with IC50 values between 543-826.4 μg/mL. Phytochemical investigation of the methanol and ethyl acetate extracts of C. abyssinica led to the isolation of five flavonoid compounds: Formononetin 1, Daidzein 2, Eriodictyol 3, Taxifolin 4, and kaempferitrin 5. The chemical structure of the isolated compounds was identified based on their physicochemical and spectroscopic analyses.

Keywords

  • Cometes abyssinica
  • Aerial parts
  • Chemical constituents
  • Flavonoids
  • Antioxidant activity
  • Antitumor activity
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