Protective Effects of Ficus benghalensis in Streptozotocin (STZ) Induced Diabetic Zebrafish (Danio rerio) Model

Indian Journal of Pharmaceutical Education and Research

  • Essa M Sabi1Clinical Biochemistry Unit, Department of Pathology, College of Medicine, King Saud University, Riyadh, SAUDI ARABIA.
  • Ahmed H Mujamammi1Clinical Biochemistry Unit, Department of Pathology, College of Medicine, King Saud University, Riyadh, SAUDI ARABIA.
  • Ziyad M Althafar2Department of Medical Laboratories Sciences, College of Applied Medical Sciences in Alquwayiyah, Shaqra University, Riyadh, SAUDI ARABIA.
  • Samia T Al-Shouli3Immunology Unit, Pathology Department, College of Medicine, King Saud University, Riyadh, SAUDI ARABIA.
  • Lotfi S Bin Dahman4Department of Medical Biochemistry, College of Medicine and Health Sciences, Hadhramout University, Mukalla, YEMEN.
  • Khalid M Sumaily1Clinical Biochemistry Unit, Department of Pathology, College of Medicine, King Saud University, Riyadh, SAUDI ARABIA.

Volume 56 Issue 3 Pages 822-829

DOI: 10.5530/ijper.56.3.134

Abstract

Background: Diabetes Mellitus (DM) is a chronic metabolic disorder that is characterized by hyperglycemia. Severe complications such as cardiovascular disease, neuropathy, nephropathy, and retinopathy are associated with DM. Objectives: To explore a safer treatment option with no/less adverse effects, we evaluated the potential of Ficus benghalensis to alleviate certain diabetic conditions. Materials and Methods: Administering streptozotocin to zebrafish intraperitoneally induced diabetes. After induction, Ficus benghalensis hydroethanolic bark extract was administered to zebrafish in different concentrations (5, 10, and 15 μg/mL). Biochemical blood parameters such as Blood Glucose, total cholesterol levels, triglycerides, and liver enzymes such as alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase were analyzed. Results: Treating the streptozotocin-induced group with Ficus benghalensis hydroethanolic bark had a hypoglycemic effect and reduced the cholesterol, triglycerides, and liver enzymes. The histopathological evaluation also showed improvement in the damaged pancreatic tissues. Conclusion: Our results suggest that Ficus benghalensis hydroethanolic bark extract can be used as a potent therapeutic candidate for treating diabetes.

Keywords

  • Diabetes mellitus
  • Ficus benghalensis
  • Alkaline phosphatase
  • Alanine
  • aminotransferase
  • Aspartate aminotransferase
  • Zebrafish
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