Effects of Arbutin on Fatty Acid Levels of Erythrocyte and Serum in Wistar Albino Rats Treated with Potassium Bromate

Indian Journal of Pharmaceutical Education and Research

  • H Turan Akkoyun1Faculty of Veterinary Science, Department of Basic Sciences, Siirt University, Siirt, TURKEY.
  • Sevinç Aydın2Çemişgezek Vocational School, Munzur University, Tunceli, TURKEY.
  • Mahire Bayramoglu Akkoyun1Faculty of Veterinary Science, Department of Basic Sciences, Siirt University, Siirt, TURKEY.
  • Aydın Şükrü Bengü3Department of Medical Services and Technics, Vocational School of Health, Bingöl University, TURKEY.
  • Suat Ekin4Van Yuzuncu Yil University, Faculty of Science, Department of Chemistry, Van, TURKEY.
  • Sinem Aslan Erdem5Faculty of Pharmacy, Department of Pharmacy Professional Sciences, Ankara University, Ankara, TURKEY.

Volume 56 Issue 3 Pages 740-747

DOI: 10.5530/ijper.56.3.123

Abstract

Background: In the presented study; the Effects of Arbutin (ARB) on the Rat Erythrocyte and serum fatty acid profile which is exposed to potassium bromate (KBrO3) were investigated. Materials and Methods: In this study, 32 Wistar albino rats weighing 250-300 g were used divided into 4 groups. Groups 1: control, group 2: KBrO3 (single dose 100 mg / kg gavage), group 3: ARB (50 mg / kg / day (ip) for 5 days), group 4: KBrO3 + ARB. At the end of the 5th day, alteration of fatty acid profile in erythrocyte and serum of rats in all groups was examined. Results: Rat serum essential fatty acid; palmitic acid (C16:0), myristic acid (C14:0), stearic acid (C18:0), oleic acid (C18:1), linoleic acid (C18:2), erythrocyte major fatty acids; palmitic acid (C16:0), myristic acid (C14:0), stearic acid (C18:0), oleic acid (C18:1), linoleic acid (C18:2), arachidic acid (C20:0), eicosenoic acid (C20:1), and lignoceric acid (C24:0). In addition, in our studied serum and erythrocytes; Total monounsaturated fatty acids (MUFA) varied between 8.91 ± 0.53- 11.71 ± 2.55 and 33.71 ± 2.12- 37.11 ± 2.12, respectively. It was determined that total polyunsaturated fatty acids (PUFA) varied between 5.90 ± 1.29- 9.96 ± 1.18 and 14.72 ± 3.66- 22.13 ± 4.82, respectively. Conclusion: In our study, alterations in fatty acid contents were observed, and results suggesting that arbutine affects the enzymes involved in Fatty acid metabolism and has an effect on fatty acid amounts.

Keywords

  • Arbutin (ARB)
  • Potassium bromate (KBrO3)
  • Fatty acid (FA)
  • Polyunsaturated
  • fatty acids (PUFA)
  • Monounsaturated fatty acids (MUFA)
  • Wistar Albino Rat
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