Synthesis of Transition Metal Complexes of Isoniazid Derivatives and Urease Inhibition Activity Detection

Indian Journal of Pharmaceutical Education and Research

  • Yi-Heng Zhang1School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou, CHINA.
  • Ze-Yu Fang1School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou, CHINA.
  • Juan Sun1School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou, CHINA.
  • Yuan-Feng Wu1School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou, CHINA.

Volume 56 Issue 2 Pages 573-579

DOI: 10.5530/ijper.56.2.80

Abstract

It have been reported that the transition metal complex of Schiff base ligands have the ability to inhibit urease. Herein, in this manuscript, two novel transition metal complexes [Cd2(L)2·(H2O)] (1), [Pb(L)·, [Pbe2) were synthesized based on chelating hydrazone ligand N‘-(pyridin-2-ylmethylene)isonicotinohydrazide (L). These compounds were tested by single crystal X-ray diffraction and determined by structure and tested for urease resistance in vitro. The complex 2 exhibited better the activities of inhibiting than the positive control acetohydroxamic acid with an IC50 =2.5 μM, while the complex 1 showed weak activity, and complex 2 acted as an effective urease inhibitor.

Keywords

  • Cadmium(II) complexes
  • Plumbum(II) complexes
  • Crystal structure
  • Schiff
  • base
  • Urease inhibitor
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