Formulation and Evaluation of Bendamustine Loaded Polymeric Nanoparticle

Indian Journal of Pharmaceutical Education and Research

  • Mallikarjun Telsang1Department of Surgery, College of Medicine, King Faisal University, Al-Ahsa, SAUDI ARABIA.
  • Pradeep D2Department of Pharmaceutics, IKON Pharmacy College, Bidadi, Karnataka, INDIA.
  • Wilson B3Department of Pharmaceutics, College of Pharmaceutical Sciences, Dayananda Sagar University, Bengaluru, Karnataka, INDIA.
  • Vasia Tamreen4Department of Pharmaceutics, Oxbridge College of Pharmacy, Bengaluru, Karnataka, INDIA.
  • Shaik Sadik5Department of Pharmacology, Oxbridge College of Pharmacy, Bengaluru, Karnataka, INDIA.
  • Mohammed Habeebuddin6Department of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa, SAUDI ARABIA.
  • Afzal Haq Asif7Department of Pharmacy Practice, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.
  • Mohammed Basheeruddin Asdaq8Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Dariyah, Riyadh, SAUDI ARABIA.
  • Sree Harsha Nagaraja9Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Hofuf, Al-Ahsa, SAUDI ARABIA., 10Department of Pharmaceutics, Vidya Siri College of Pharmacy, Off Sarjapura Road, Bangalore, INDIA.
  • Syed Dawood Noor11Department of Pharmacognosy, Vidya Siri College of Pharmacy, Off Sarjapura Road, Bangalore, INDIA.

Volume 56 Issue 2 Pages 414-419

DOI: 10.5530/ijper.56.2.61

Abstract

Background: Bendamustine-loaded albumin nanoparticles were prepared using different concentrations of Bovine Serum Albumin (BSA) with the goal of delivering the medication to particular cancer cells. Materials and Procedures: The nanoparticles were prepared using simple coacervation technique with increasing concentrations of BSA. The nanoparticles were characterized for process yield, particle size, surface morphology, drug loading capacity (%), particle size distribution (Polydispersity index), in-vitro drug release. The drug release kinetics were studies using different dissolution models. The drug loading capacity of the produced nanoparticles varied from 10.4% to 19%. Formulation (F1) had a mean particle size of approximately 122.4 nm and polydispersivity index of 0.432 across the different compositions. Bendamustine nanoparticles exhibit sustained drug release with almost 51.8% bendamustine released in one day. The drug release kinetics follows Korsmeyer-Peppas model with a Fickian drug release mechanism. The Bendamustine nanoparticles were found to be stable for a month at 40±5C and 75±5% relative humidity. Conclusion: Bendamustine loaded BSA nanoparticles were developed which were found to exhibit a sustained drug release profile. Albumin based Bendamustine nanoparticles have the potential to be explored further for the better management of the cancer chemotherapy with reduced side effects.

Keywords

  • Nanoparticles
  • Bendamustine
  • Cancer
  • Bovine serum albumin
  • Bendamustine
  • albumin
  • Release kinetics
  • Surface morphology
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