Enteric Dissolution Enhancement of Engineered Gastro Resistant Omeprazole Tablets using Hydroxypropyl Methylcellulose Acetate Succinate

Indian Journal of Pharmaceutical Education and Research

  • Sagar Kumar Mohapatra1Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, INDIA.
  • Rudra Narayan Sahoo1Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, INDIA., 2School of Pharmacy and Life Sciences, Centurion University of Technology and Management, Odisha, INDIA.
  • Subrata Mallick1Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, INDIA.
  • Rajaram Mohapatra1Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, INDIA.

Volume 55 Issue 3 Pages 677-684

DOI: 10.5530/ijper.55.3.139

Abstract

Purpose: Oral drug delivery system has always been a preferred choice for the treatment of peptic ulcer and gastroesophageal reflux diseases. Being a proton pump inhibitor omeprazole restricts gastric acid secretion but the foremost downside is its degradation in acidic environments. The systemic absorption of gastro-unstable drugs can be improved by the enteric coating. Materials and Methods: This study was aimed at developing an effective enteric coating for omeprazole tablets using HPMC E5-LV and Hydroxypropyl Methylcellulose Acetate Succinate (HPMC-AS) polymers. The core tablets were subcoated with HPMC E5-LV which acted as a barrier between core tablet and enteric coated tablet. The enteric coating was applied using HPMC-AS. Results: Dissolution information unveiled that the enteric coat remained in place for 2 hr in acidic medium (0.1N HCl) and later dissolved when came in contact with basic media (acetate buffer pH 6.8), it dissolved within a jiffy. Conclusion: The release profile showed 91 to 98% drug release within 1hr in pH 6.8 Acetate buffer. Further instrumental analysis was performed to ascertain drug-polymer interaction.

Keywords

  • Proton pump inhibitor
  • Enteric coating
  • HPMC
  • Omeprazole
  • Dissolution enhancement
IJOPP

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