Tribulus terrestris Saponins Improve Ovarian Ischemia-reperfusion Injury in Female Rats: Modulation of Vascular Endothelial Growth Factor-A and Hemeoxygenase-1

Indian Journal of Pharmaceutical Education and Research

  • Asmaa Mohamed Abdel-Aziz1Department of Pharmacology, Faculty of Medicine, Minia University, Minia, EGYPT.
  • Hanaa Hassanein Mohammed2Department of Histology and Cell Biology, Faculty of Medicine, Minia University, Minia, EGYPT.
  • Osama Abdelazem3Department of Obstetrics and Gynecology, Faculty of Medicine, Al-Azhar University, Assuit, EGYPT.
  • Rasha Fouad Ahmed4Department of Medical Biochemistry, Faculty of Medicine, Minia University, Minia University, Minia, EGYPT.
  • Yasmine F. Ibrahim1Department of Pharmacology, Faculty of Medicine, Minia University, Minia, EGYPT.

Volume 55 Issue 1 Pages 240-248

DOI: 10.5530/ijper.55.1.27

Abstract

Aim/Background: Ovarian I/R is a popular gynecological emergency, complicating ovarian torsion. TTS, reported to have many therapeutic effects along with being an antioxidant, anti- inflammatory and anti-apoptotic agent. The aim of this study was to estimate the probable protective role of Tribulus terrestris Saponin (TTS) in recovering the damaging effects of ischemia-reperfusion (I/R) in the female rats' ovarian tissue. Materials and Methods: TTS was treated to female rats in presence or absence of ovarian I/R. Results: I/R caused ovarian damage, represented by deformity in normal ovarian histological structure, with a significant oxidative and nitrosative stress along with obvious inflammatory damage. Pretreatment with TTS significantly reversed the I/R induced ovarian toxic effects. TTS may have valuable ovarian protective effects against ovarian I/R injury. Conclusion: TTS protection is given via antioxidant, anti-nitrosative, anti-inflammatory and anti-apoptotic mechanisms with advancement of vascular angiogenesis and pituitary-gonadal axis up regulation.

Keywords

  • Apoptosis
  • Angiogenesis
  • Immunohistochemical study
  • Ovarian ischemia/
  • reperfusion
  • Tribulus terrestris saponin
IJOPP

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