Fabrication of Triprolidine∙HCl Transdermal Drug Delivery System and Pharmacokinetic Studies
Indian Journal of Pharmaceutical Education and Research
Afzal Haq Asif1Department of Pharmacy Practice, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.
Niranjan Puttaswamy Hodalur2Department of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa, SAUDI ARABIA.
Nagaraja Sreeharsha3Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA., 4Department of Pharmaceutics, Vidya Siri College of Pharmacy, Off Sarjapur Road, Bangalore, INDIA.
Jagadeesh Gurupadayya Hiremath5Department of Pharmaceutics, PA College of Pharmacy, Mangalore, INDIA.
Keyur Shileshbhai Mistry6Department of Pharmaceutics, KLE University, Belgaum, Karnataka, INDIA.
Bandar E Al-Dhubiab3Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.
Girish Meravanige2Department of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa, SAUDI ARABIA.
Ranjith Kumar Karnati7Department of Chemistry, College of Science, King Faisal University, Hofuf, SAUDI ARABIA.
Saleemulla Khan8Department of Pharmacognosy PA College of Pharmacy, Mangalore, INDIA.
Muhammed Mubin9Department of Pharmaceutical Chemistry, PA College of Pharmacy, Mangalore, INDIA.
Aiswarya Thelakkadan Chathoth9Department of Pharmaceutical Chemistry, PA College of Pharmacy, Mangalore, INDIA.
The purpose was to examine and analyze the matrix system of Triprolidine∙HCl wth the selected polymer ethyl cellulose. We achieved in vitro permeation studies using Keshary Chien diffusion cells across guinea pig skin. Considering the success of permeation enhancers with differing concentrations to enhance the permeation rate. The performed the in vitro dissolution of the developed transdermal patches. The in vivo analysis was carried out on male albino rabbits the drug release was determined by high performance liquid chromatography. The significant high performance liquid chromatography retention time of triprolidine∙HCl was 4.0 min. The limit of detection was 10 ng/mL and quantification limit of was 17 ng/ml. The area under curve was found to be 646.39 ng/ml.hr with the Kel was 0.0682 and Ka was 0.184 hour-1. The peak plasma concentration 24.54 ng/ml were produced in peak time of 8.58 hrs with the half life of 10.16 hrs.
