Fabrication of Poly (Sebacic acid-co-ricinoleic-ester anhydride) with β-cyclodextrin-loaded Doxorubicin Implants and in vitro Characterization
Indian Journal of Pharmaceutical Education and Research
Nagaraja Sreeharsha1Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA., 9Department of Pharmaceutics, Vidya Siri College of Pharmacy, Off Sarjapura Road, Bangalore, INDIA.
Jagadeesh G Hiremath2Department of Pharmaceutics, PA College of Pharmacy, Mangalore, Karnataka, INDIA.
Bandar E Al-Dhubiab1Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.
Girish Meravanige3Department of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa, SAUDI ARABIA.
Ranjith Kumar Karnati4Department of Chemistry, College of Science, King Faisal University, Al-Ahsa, SAUDI ARABIA.
Mahesh Attimarad1Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.
Anroop B Nair1Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.
Katharigatta N Venugopal1Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA., 10Department of Biotechnology and Food Technology, Durban University of Technology, Durban, SOUTH AFRICA.
Mohamed A Morsy1Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA., 8Department of Pharmacology, Faculty of Medicine, Minia University, El-Minia 61511, EGYPT.
Shinu Pottathil5Department of Biomedical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.
Saleemmulla Khan6Department of Pharmacognosy, PA College of Pharmacy, Mangalore, Karnataka, INDIA.
Nagashekhara Molugulu7School of Pharmacy, Monash University, Jalan Lagoon Selatan, Bandar Sunway, Selangor, MALAYSIA.
Background: Doxorubicin is an excellent molecule for the formation of biodegradable implants using the poly (sebacic acid-co-ricinoleic-ester anhydride) 70:30 w/w (poly[SARA] 70:30 w/w PSRA 7/3) polymer. Methods: The cylindrical implants were successfully produced by means of hot melt extrusion. We used differential scanning calorimetric (DSC) and X-ray diffraction (XRD) methods to identify the melting state and crystal type of blank and drug-loaded implants. A study was conducted on PSRA 7/3 w/w blank and drug-loaded implants for in vitro hydrolytic degradation. The drug present in the remaining sample was estimated. Results: The hydrolytic degradation rate of the 10% w/w (F2)-loaded implant was relatively low when compared with the 20% w/w (F3) implant. Discussion: In vitro drug release studies illustrated that the drug-release rate was faster in association with increasing amounts of doxorubicin in the implant.
