Modified Pectins for Colon-Specific Drug Delivery

Indian Journal of Pharmaceutical Education and Research

  • Aneesh Muvva1Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, INDIA.
  • Indhu Annie Chacko1Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, INDIA.
  • Vivek Ghate1Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, INDIA.
  • Shaila Angela Lewis1Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, INDIA.

Volume 54 Issue 2s Pages s12-s18

DOI: 10.5530/ijper.54.2s.57

Abstract

Treatment of local diseases such as ulcerative colitis, Crohn’s disease, irritable bowel syndrome and colonic cancer by targeting drug to the colon is a viable approach. Due to gastric degradation of drugs, proteins and peptides, only minimum amount of drug gets absorbed when administered orally and shows little therapeutic activity. Hence the strategy of delivering drugs to colon known as colon targeted drug delivery evolved. Pectin a naturally occurring biodegradable polysaccharide has gained importance as a carrier for colon-specific delivery attributed to swelling nature as well as the ability to resist gastric degradation. This review describes the chemistry of pectin, mechanism of action and various novel modified pectin formulations aimed at targeting the colon.

Keywords

  • Colon targeting
  • Intestinal microflora
  • Modified pectin forms
  • Gelling property
  • biodegradable polysaccharide
  • Drug delivery
IJOPP

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