Formulation and Evaluation of Tamoxifen Citrate Loaded Transdermal Reservoir Gel Drug Delivery Systems
Indian Journal of Pharmaceutical Education and Research
Nagaraja SreeHarsha1Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA., 4Department of Pharmaceutics, Vidya Siri College of Pharmacy, Bangalore, Karnataka, INDIA.
Jagadeesh G Hiremath4Department of Pharmaceutics, Vidya Siri College of Pharmacy, Bangalore, Karnataka, INDIA.
Bimlesh Kumar Rawre2Department of Pharmaceutics, East West College of Pharmacy, Bengaluru, Karnataka, INDIA.
Niranjan Puttaswamy5Department of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa, SAUDI ARABIA.
Bandar E Al-Dhubiab1Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.
Katharigatta N. Venugopala1Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA., 3Department of Biotechnology and Food Technology, Durban University of Technology, Durban, SOUTH AFRICA.
Sabah H Akrawi1Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.
Girish Meravanige5Department of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa, SAUDI ARABIA.
Mahesh Attimarad1Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.
Anroop B Nair1Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.
Background: Successful treatment of cancer is yet remained as a challenging concern in
public health. Transdermal delivery of hormonal therapy offers several advantages over
the oral route associated with potential side effects. Methods: The present investigation
preparation and screening of rate controlling membranes using Eudragit release liners
of RS 100, hydroxyl propyl methyl cellulose K4M (HPMC K4M) and ethyl cellulose by
plate casting method and their physicochemical characterization. The prepared release
liners were subjected for preformualtion studies (thickness, weight variation, moisture
uptake, folding endurance and moisture loss). Tamoxifen citrate is an ideal molecule for
the transdermal reservoir for the preparation of gel dosage form due its dosage regimen.
Results: The main investigation, topical gel TC was prepared using HPMC K4M and
Carbopol 934 as gelling agents in different proportions with Dimethyl Sulfoxide (DMSO)
as a penetration enhancer. TC gels were subjected for the physicochemical parameters
such as pH, viscosity, spreadability. Conclusion: The TC gel diffusion was conducted
by using rate controlling membranes (release liner). The TC gel skin permeation was
investigated by using excised rat skin as a barrier.
